Tissue Typing Center, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Zagreb, Croatia.
HLA. 2018 Dec;92 Suppl 2:51-56. doi: 10.1111/tan.13401.
The aim of this report was to compare our data with data presented in the European Federation for Immunogenetics (EFI) catalogue (version 1.0) and to evaluate whether or not current (CUR) HLA alleles found in the Croatian population fall into the same categories of common (COM) or well-documented (WD) HLA alleles as those listed in the EFI catalogue. Among 237 HLA-A, -B, -DRB1 alleles observed in the Croatian population so far, 181 alleles were observed ≥3 times. According to our criteria, 36 alleles at HLA-A locus, 71 alleles at HLA-B locus and 51 alleles at HLA-DRB1 locus were characterised as CUR in Croatia (COM or WD in EFI catalogue), while 23 local HLA alleles are not listed at all among COM or WD alleles in EFI catalogue.
本报告的目的是将我们的数据与欧洲免疫遗传学联合会（EFI）目录（第 1.0 版）中提供的数据进行比较，并评估克罗地亚人群中当前（CUR）HLA 等位基因是否属于 EFI 目录中列出的常见（COM）或有充分文件证明的（WD）HLA 等位基因类别。迄今为止，在克罗地亚人群中观察到的 237 个 HLA-A、-B、-DRB1 等位基因中，有 181 个等位基因观察到≥3 次。根据我们的标准，HLA-A 基因座有 36 个等位基因、HLA-B 基因座有 71 个等位基因和 HLA-DRB1 基因座有 51 个等位基因被确定为克罗地亚的 CUR（EFI 目录中的 COM 或 WD），而 23 个本地 HLA 等位基因在 EFI 目录中的 COM 或 WD 等位基因中根本没有列出。
