Electrical Engineering Department, National Institute of Technology, Silchar 788010, Assam, India.
Electrical Engineering Department, Institute of Infrastructure Technology Research and Management, Ahmedabad 380026, Gujarat, India.
IET Syst Biol. 2018 Oct;12(5):219-225. doi: 10.1049/iet-syb.2017.0093.
Here, a direct adaptive control strategy with parametric compensation is adopted for an uncertain non-linear model representing blood glucose regulation in type 1 diabetes mellitus patients. The uncertain parameters of the model are updated by appropriate design of adaptation laws using the Lyapunov method. The closed-loop response of the plasma glucose concentration as well as external insulin infusion rate is analysed for a wide range of variation of the model parameters through extensive simulation studies. The result indicates that the proposed adaptive control scheme avoids severe hypoglycaemia and gives satisfactory performance under parametric uncertainty highlighting its ability to address the issue of inter-patient variability.
这里，针对代表 1 型糖尿病患者血糖调节的不确定非线性模型，采用了具有参数补偿的直接自适应控制策略。模型的不确定参数通过使用 Lyapunov 方法设计适当的自适应律进行更新。通过广泛的仿真研究，分析了模型参数大范围变化时血浆葡萄糖浓度和外部胰岛素输注率的闭环响应。结果表明，所提出的自适应控制方案避免了严重的低血糖，并在参数不确定性下表现出令人满意的性能，突出了其解决患者间变异性问题的能力。
