Department of Electrical and Computer Engineering, COMSATS University Islamabad, Islamabad, Pakistan.
Center for Advanced Studies in Telecommunications (CAST), COMSATS University Islamabad, Islamabad, Pakistan.
IET Syst Biol. 2020 Dec;14(6):307-313. doi: 10.1049/iet-syb.2018.5075.
In Diabetes Mellitus, the pancreas remains incapable of insulin administration that leads to hyperglycaemia, an escalated glycaemic concentration, which may stimulate many complications. To circumvent this situation, a closed-loop control strategy is much needed for the exogenous insulin infusion in diabetic patients. This closed-loop structure is often termed as an artificial pancreas that is generally established by the employment of different feedback control strategies. In this work, the authors have proposed an arbitrary-order sliding mode control approach for development of the said mechanism. The term, arbitrary, is exercised in the sense of its applicability to any -order controllable canonical system. The proposed control algorithm affirms the finite-time effective stabilisation of the glucose-insulin regulatory system, at the desired level, with the alleviation of sharp fluctuations. The novelty of this work lies in the sliding manifold that incorporates indirect non-linear terms. In addition, the necessary discontinuous terms are filtered-out once before its employment to the plant, i.e. diabetic patient. The robustness, in the presence of external disturbances, i.e. meal intake is confirmed via rigorous mathematical stability analysis. In addition, the effectiveness of the proposed control strategy is ascertained by comparing the results with the standard literature.
在糖尿病中，胰腺仍然无法分泌胰岛素，导致高血糖，即血糖浓度升高，这可能会刺激多种并发症。为了避免这种情况，糖尿病患者需要一种闭环控制策略来进行外源性胰岛素输注。这种闭环结构通常被称为人工胰腺，它通常是通过采用不同的反馈控制策略来建立的。在这项工作中，作者提出了一种任意阶滑模控制方法来开发这种机制。“任意”一词的含义是指它适用于任何阶可控规范系统。所提出的控制算法能够在期望的水平上实现葡萄糖-胰岛素调节系统的有限时间有效稳定，同时减轻了急剧波动。这项工作的新颖之处在于滑模面中包含了间接非线性项。此外，在将其应用于植物（即糖尿病患者）之前，先将必要的不连续项过滤掉。通过严格的数学稳定性分析，确认了在存在外部干扰（如进餐）时的鲁棒性。此外，通过与标准文献的结果进行比较，确定了所提出的控制策略的有效性。
