Cockerell G L, Parodi A L, Levy D
Vet Immunol Immunopathol. 1986 Nov;13(3):189-202. doi: 10.1016/0165-2427(86)90072-3.
The humoral and cellular immunological reactivity of sheep were studied throughout the first 32 weeks following experimental infection with bovine leukemia virus (BLV). Seroconversion of BLV-inoculated sheep occurred within 4 weeks, but infection was not transmitted to contact control sheep. Despite the persistence of the viral infection, no differences were demonstrated in leukograms, serum IgG concentrations, humoral response to immunization with an irrelevant antigen (rabbit red blood cells), phytomitogen (Concanavalin A and Pokeweek mitogen)-induced lymphocyte blastogenesis, or chemical (1-chloro, 2-4 dinitrobenzene) skin contact hypersensitivity, between BLV-infected and uninfected contact control sheep. These results demonstrate the absence of a nonspecific immunosuppressive effect of BLV and further negate the influence of a generalized immunological deficit on the development of clinical disease in BLV-infected animals.
在实验感染牛白血病病毒（BLV）后的前32周内，对绵羊的体液免疫和细胞免疫反应性进行了研究。接种BLV的绵羊在4周内发生血清转化，但感染未传播给接触对照组绵羊。尽管病毒感染持续存在，但在BLV感染的绵羊和未感染的接触对照组绵羊之间，在白细胞计数、血清IgG浓度、对无关抗原（兔红细胞）免疫的体液反应、植物血凝素（刀豆球蛋白A和商陆有丝分裂原）诱导的淋巴细胞增殖，或化学物质（1-氯，2,4-二硝基苯）皮肤接触超敏反应方面，均未显示出差异。这些结果表明BLV不存在非特异性免疫抑制作用，并进一步否定了全身性免疫缺陷对BLV感染动物临床疾病发展的影响。
