Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias extractivas IPN, Av. Instituto Politecnico Nacional S/N Unidad Profesional Adolfo Lopez Mateos Zacatenco, Mexico DF, Mexico.
Plant Foods Hum Nutr. 2010 Dec;65(4):350-7. doi: 10.1007/s11130-010-0181-5.
The hypoglycemic effects of hexane, chloroform and methanol extracts from fruits and seeds of Byrsonima crassifolia were evaluated by oral administration to normoglycemic and streptozotocin-induced severe diabetic rats (SD). The anti-diabetic effect was examined by blood glucose, triglycerides, lipid peroxidation, total cholesterol levels in the serum, glycogen content of liver and skeletal muscles, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and oxidized glutathione (GSSG) levels. The most active extracts were obtained with hexane. Hexane and chloroform extracts from fruits and seeds of Byrsonima crassifolia increased the levels of SOD, GSH, GSSG and CAT, hepatic glycogen content, glucose-6-phosphatase (G6Pase) and the plasma insulin levels. They also decreased glucokinase (GK) and TBAR (thiobarbituric acid assay). In conclusion, Byrsonima crassifolia possesses significant antihyperglycemic properties after 4 h of a single oral dose. It can also improve hyperlipidemia and hyperinsulinemia in streptozotocin-induced diabetic rats. Both extracts exhibited significant inhibitory activity against AGEs (advanced glycation end products) formation with IC(50) values ranging from 94.3 to 138.7 μg/ml. Therefore, B. crassifolia can be considered as a potential safe anti-diabetic agent.
采用腹腔注射链脲佐菌素（STZ）诱导建立严重糖尿病大鼠（SD）模型，观察巴西叶（Byrsonima crassifolia）的果实和种子的正己烷、氯仿和甲醇提取物的降血糖作用。通过检测血糖、甘油三酯、血清脂质过氧化、总胆固醇水平、肝和骨骼肌糖原含量、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽（GSH）和氧化型谷胱甘肽（GSSG）水平，评价其抗糖尿病作用。结果表明，正己烷提取物活性最高。巴西叶的果实和种子的正己烷、氯仿提取物能提高 SOD、GSH、GSSG 和 CAT 水平，增加肝糖原含量，提高葡萄糖-6-磷酸酶（G6Pase）和血浆胰岛素水平，降低葡糖激酶（GK）和 TBAR（硫代巴比妥酸反应物质）水平。结论：巴西叶经单次口服给药 4 h 后具有显著的降血糖作用，还能改善链脲佐菌素诱导的糖尿病大鼠的高血脂和高胰岛素血症。两种提取物对 AGEs（晚期糖基化终产物）的形成具有显著的抑制活性，IC50 值范围为 94.3 至 138.7 μg/ml。因此，巴西叶可以作为一种有潜力的安全抗糖尿病药物。
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