富含槲皮素的洋葱皮提取物对高脂饮食喂养的C57BL/6J小鼠的降胆固醇作用。
Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet.
作者信息
Kang Hyun-Ju, Pichiah Pichiah Balasubramanian Tirupathi, Abinaya Ravichandran Vijaya, Sohn Hee-Sook, Cha Youn-Soo
机构信息
Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University, Jeonju, Jeonbuk, 54896 Korea.
出版信息
Food Sci Biotechnol. 2016 Jun 30;25(3):855-860. doi: 10.1007/s10068-016-0141-4. eCollection 2016.
Abstract
Onion peel (OP) extract is known as a rich source of flavonoids, mainly quercetin. We hypothesized that OP has hypocholesterolemic effects. To investigate the effect of OP, C57BL/6J mice were divided into 4 dietary groups (=10); normal diet (ND); high cholesterol diet (HC); and high cholesterol diet with 100 or 200 mg OP extract (OP-100 or OP-200, respectively) per kg of body weight. After 12 weeks, lower values of liver weight, serum total cholesterol levels, LDL cholesterol, atherogenic index, cardiac risk factor, hepatic triacylglycerol, and total cholesterol, and higher fecal cholesterol levels were observed in the OP-200 than in the HC group. The hepatic mRNA expression levels of low-density lipoprotein receptors (LDL-R) and cholesterol 7-alpha-monooxygenase (CYP7A1) were high in the OP-200 compared to the HC group. These observations suggest that OP promoted lowering of serum and hepatic cholesterol in mice primarily via fecal excretion.
摘要
洋葱皮（OP）提取物是黄酮类化合物的丰富来源，主要是槲皮素。我们假设OP具有降胆固醇作用。为了研究OP的作用，将C57BL/6J小鼠分为4个饮食组（每组10只）：正常饮食（ND）组；高胆固醇饮食（HC）组；以及每千克体重分别添加100或200毫克OP提取物的高胆固醇饮食组（分别为OP-100或OP-200组）。12周后，与HC组相比，OP-200组的肝脏重量、血清总胆固醇水平、低密度脂蛋白胆固醇、致动脉粥样硬化指数、心脏危险因素、肝脏三酰甘油和总胆固醇值较低，粪便胆固醇水平较高。与HC组相比，OP-200组肝脏中低密度脂蛋白受体（LDL-R）和胆固醇7-α-单加氧酶（CYP7A1）的mRNA表达水平较高。这些观察结果表明，OP主要通过粪便排泄促进小鼠血清和肝脏胆固醇的降低。
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