Lin T M, Tsu W T, Chen C J
Br J Cancer. 1986 Dec;54(6):969-76. doi: 10.1038/bjc.1986.269.
A study of mortality from hepatoma and hepatic cirrhosis was conducted in Taiwan, where their mortality rates are among the highest in the world in 1980 being 26.10 and 8.14 per 100,000 population for males and females, respectively, for hepatoma, and 33.01 and 12.90 for males and females, respectively, for cirrhosis. The secular trends of hepatoma and hepatic cirrhosis death rates have been increasing, especially in males, with consequent increase in the sex ratio. The large difference in mortality rates between males and females and the increasing trends in the sex ratio suggest that other factors besides hepatitis B virus (HBV), are involved in the aetiology of hepatoma and cirrhosis of liver.
在台湾开展了一项关于肝癌和肝硬化死亡率的研究，1980年该地的肝癌和肝硬化死亡率位居世界前列，男性肝癌死亡率为每10万人26.10例，女性为每10万人8.14例；男性肝硬化死亡率为每10万人33.01例，女性为每10万人12.90例。肝癌和肝硬化死亡率的长期趋势一直在上升，尤其是男性，导致性别比增加。男性和女性死亡率的巨大差异以及性别比的上升趋势表明，除了乙型肝炎病毒（HBV）之外，其他因素也参与了肝癌和肝硬化的病因。
