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美国择期经皮冠状动脉介入治疗后当日出院与成本和结局的关系。

Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes.

机构信息

Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri.

Barnes-Jewish Hospital, St Louis, Missouri.

出版信息

JAMA Cardiol. 2018 Nov 1;3(11):1041-1049. doi: 10.1001/jamacardio.2018.3029.

Abstract

IMPORTANCE

Same-day discharge (SDD) after elective percutaneous coronary intervention (PCI) is associated with lower costs and preferred by patients. However, to our knowledge, contemporary patterns of SDD after elective PCI with respect to the incidence, hospital variation, trends, costs, and safety outcomes in the United States are unknown.

OBJECTIVE

To examine (1) the incidence and trends in SDD; (2) hospital variation in SDD; (3) the association between SDD and readmissions for bleeding, acute kidney injury (AKI), acute myocardial infarction (AMI), or mortality at 30, 90, and 365 days after PCI; and (4) hospital costs of SDD and its drivers.

DESIGN, SETTING, AND PARTICIPANTS: This observational cross-sectional cohort study included 672 470 patients enrolled in the nationally representative Premier Healthcare Database who underwent elective PCI from 493 hospitals between January 2006 and December 2015 with 1-year follow-up.

EXPOSURES

Same-day discharge, defined by identical dates of admission, PCI procedure, and discharge.

MAIN OUTCOMES AND MEASURES

Death, bleeding requiring a blood transfusion, AKI and AMI at 30, 90, or 365 days after PCI, and costs from hospitals' perspective, inflated to 2016.

RESULTS

Among 672 470 elective PCIs, 221 997 patients (33.0%) were women, 30 711 (4.6%) were Hispanic, 51 961 (7.7%) were African American, and 491 823 (73.1%) were white. The adjusted rate of SDD was 3.5% (95% CI, 3.0%-4.0%), which increased from 0.4% in 2006 to 6.3% in 2015. We observed substantial hospital variation for SDD from 0% to 83% (median incidence rate ratio, 3.82; 95% CI, 3.48-4.23), implying an average (median) 382% likelihood of SDD at one vs another hospital. Among SDD (vs non-SDD) patients, there was no higher risk of death, bleeding, AKI, or AMI at 30, 90, or 365 days. Same-day discharge was associated with a large cost savings of $5128 per procedure (95% CI, $5006-$5248), driven by reduced supply and room and boarding costs. A shift from existing SDD practices to match top-decile SDD hospitals could annually save $129 million in this sample and $577 million if adopted throughout the United States. However, residual confounding may be present, limiting the precision of the cost estimates.

CONCLUSIONS AND RELEVANCE

Over 2006 to 2015, SDD after elective PCI was infrequent, with substantial hospital variation. Given the safety and large savings of more than $5000 per PCI associated with SDD, greater and more consistent use of SDD could markedly increase the overall value of PCI care.

摘要

重要性

择期经皮冠状动脉介入治疗(PCI)后的当日出院(SDD)与降低成本和患者偏好相关。然而,据我们所知,在美国,关于择期 PCI 后 SDD 的发生率、医院差异、趋势、成本和安全结局的当代模式尚不清楚。

目的

研究(1)SDD 的发生率和趋势;(2)医院之间 SDD 的差异;(3)SDD 与 30、90 和 365 天后因出血、急性肾损伤(AKI)、急性心肌梗死(AMI)或死亡而再次入院之间的关联;以及(4)SDD 及其驱动因素的医院成本。

设计、设置和参与者:这项观察性横截面队列研究纳入了 2006 年 1 月至 2015 年 12 月期间在全国代表性 Premier Healthcare Database 中接受择期 PCI 的 493 家医院的 672470 名患者,随访时间为 1 年。

暴露

SDD 通过相同的入院、PCI 手术和出院日期来定义。

主要结局和测量

从医院角度来看,死亡、需要输血的出血、30、90 或 365 天后的 AKI 和 AMI 以及成本。

结果

在 672470 例择期 PCI 中,221997 例(33.0%)为女性,30711 例(4.6%)为西班牙裔,51961 例(7.7%)为非裔美国人,491823 例(73.1%)为白人。SDD 的调整后发生率为 3.5%(95%CI,3.0%-4.0%),从 2006 年的 0.4%增加到 2015 年的 6.3%。我们观察到 SDD 的医院间存在很大的差异,从 0%到 83%(中位数发生率比,3.82;95%CI,3.48-4.23),这意味着在一家医院与另一家医院相比,SDD 的平均(中位数)可能性高 382%。在 SDD(与非 SDD)患者中,30、90 或 365 天后,死亡、出血、AKI 或 AMI 的风险没有更高。SDD 与每例手术 5128 美元的巨大成本节约相关(95%CI,5006-5248),这主要归因于供应和房间及住宿费用的降低。如果在现有 SDD 实践的基础上进行转变,以匹配排名前十分位数的 SDD 医院,那么在该样本中每年可节省 1.29 亿美元,如果在美国全面推广,每年可节省 5.77 亿美元。然而,可能存在残余混杂因素,限制了成本估计的准确性。

结论和相关性

2006 年至 2015 年期间,择期 PCI 后的 SDD 并不常见,且医院间差异较大。鉴于 SDD 与 PCI 相关的安全性和超过 5000 美元的巨大成本节约,更多和更一致地使用 SDD 可以显著提高 PCI 护理的整体价值。

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