Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA; Department of Biology, Syracuse University, Syracuse, NY 13210, USA.
Curr Opin Cell Biol. 2019 Feb;56:45-52. doi: 10.1016/j.ceb.2018.09.001. Epub 2018 Sep 28.
The ability to divide is a fundamental property of a living cell. The 3D orientation of cell division is essential for embryogenesis, maintenance of tissue organization and architecture, as well as controlling cell fate. Much attention has been placed on the mitotic spindle's role in placing itself along the cell's longest axis, where a shape sensing mechanism between a population of microtubules extending from mitotic centrosomes to the cell cortex occurs. However, contractile forces at the cell cortex also likely play a decisive role in determining the final placement of daughter cells following division. In this review, we discuss recent literature that describes the role of these contractile forces and how these forces could be balanced by mitotic adhesion complexes.
分裂能力是活细胞的基本特性。细胞分裂的 3D 方向对于胚胎发生、组织的维持和结构以及控制细胞命运至关重要。人们非常关注有丝分裂纺锤体在沿着细胞最长轴放置自身的作用，在有丝分裂中心体延伸到细胞皮质的微管群体之间发生一种形状感应机制。然而，细胞皮质的收缩力也可能在决定分裂后子细胞的最终位置方面发挥决定性作用。在这篇综述中，我们讨论了最近描述这些收缩力作用的文献，以及这些力如何通过有丝分裂黏附复合物来平衡。
