Bradshaw Andrew, Sylakowski Kyle, Wells Alan
Departments of Pathology and Bioengineering, and the McGowan, Institute for Regenerative Medicine, University of Pittsburgh, and VA Pittsburgh Health System, Pittsburgh PA 15213 USA.
Curr Pathobiol Rep. 2018 Jun;6(2):109-115. doi: 10.1007/s40139-018-0167-9. Epub 2018 Mar 20.
Stem cells have been proposed as sources for tissue replacement when healing does not occur. These cells could contribute directly to skin structures via differentiation, or via producing trophic factors that would 'educate' the micro-environment to encourage tissue repair. Studies in animals have supported both mechanisms, but translation to humans has been challenged by poor cell survival after transplantation. However, the improvement noted with even transient existence suggests another new possibility, that of suppressing the inflammatory response that limits regenerative healing. Herein, we will propose that this immunomodulatory aspect holds promise for promoting skin healing.
We have found that stem cell transplantation into wounds can dampen both acute and chronic inflammation, leading to more regenerative-like healing and diminished scarring.
Wound healing could be improved by dampening inflammation both initially to allow for tissue replacement to proceed and late to reduce scarring.
当伤口无法愈合时，干细胞被提议作为组织替代的来源。这些细胞可通过分化直接参与皮肤结构的形成，或通过产生营养因子来“引导”微环境以促进组织修复。动物研究支持了这两种机制，但向人类的转化受到移植后细胞存活率低的挑战。然而，即使短暂存在所观察到的改善提示了另一种新的可能性，即抑制限制再生愈合的炎症反应。在此，我们提出这种免疫调节作用有望促进皮肤愈合。
我们发现将干细胞移植到伤口中可减轻急性和慢性炎症，从而导致更类似再生的愈合并减少瘢痕形成。
通过在初期减轻炎症以促进组织替代进行，并在后期减轻炎症以减少瘢痕形成，有望改善伤口愈合。
