p48v-myb介导的转化不需要env编码的残基。
env-encoded residues are not required for transformation by p48v-myb.
作者信息
Lipsick J S, Ibanez C E
出版信息
J Virol. 1987 Mar;61(3):933-6. doi: 10.1128/JVI.61.3.933-936.1987.
Abstract
The v-myb oncogene of avian myeloblastosis virus induces acute myeloblastic leukemia in chickens and transforms avian myeloid cells in vitro. The protein product of this oncogene, p48v-myb, is partially encoded by the retroviral gag and env genes. We demonstrated that the env-encoded carboxyl terminus of p48v-myb is not required for transformation. Our results showed, in addition, that a coding region of c-myb which is not essential for transformation was transduced by avian myeloblastosis virus.
摘要
禽成髓细胞瘤病毒的v-myb癌基因可在鸡中诱发急性髓细胞白血病，并在体外转化禽髓细胞。该癌基因的蛋白质产物p48v-myb部分由逆转录病毒的gag和env基因编码。我们证明p48v-myb的env编码羧基末端对于转化并非必需。此外，我们的结果表明，禽成髓细胞瘤病毒转导了c-myb的一个对转化并非必需的编码区域。
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