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p48v-myb介导的转化不需要env编码的残基。

env-encoded residues are not required for transformation by p48v-myb.

作者信息

Lipsick J S, Ibanez C E

出版信息

J Virol. 1987 Mar;61(3):933-6. doi: 10.1128/JVI.61.3.933-936.1987.

DOI:10.1128/JVI.61.3.933-936.1987
PMID:3027417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254042/
Abstract

The v-myb oncogene of avian myeloblastosis virus induces acute myeloblastic leukemia in chickens and transforms avian myeloid cells in vitro. The protein product of this oncogene, p48v-myb, is partially encoded by the retroviral gag and env genes. We demonstrated that the env-encoded carboxyl terminus of p48v-myb is not required for transformation. Our results showed, in addition, that a coding region of c-myb which is not essential for transformation was transduced by avian myeloblastosis virus.

摘要

禽成髓细胞瘤病毒的v-myb癌基因可在鸡中诱发急性髓细胞白血病，并在体外转化禽髓细胞。该癌基因的蛋白质产物p48v-myb部分由逆转录病毒的gag和env基因编码。我们证明p48v-myb的env编码羧基末端对于转化并非必需。此外，我们的结果表明，禽成髓细胞瘤病毒转导了c-myb的一个对转化并非必需的编码区域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde6/254042/97a5e3c3f512/jvirol00094-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde6/254042/193d2a87b99e/jvirol00094-0304-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde6/254042/a16d1d4bf315/jvirol00094-0305-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde6/254042/219324d3f434/jvirol00094-0305-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde6/254042/97a5e3c3f512/jvirol00094-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde6/254042/193d2a87b99e/jvirol00094-0304-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde6/254042/a16d1d4bf315/jvirol00094-0305-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde6/254042/219324d3f434/jvirol00094-0305-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde6/254042/97a5e3c3f512/jvirol00094-0306-a.jpg

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1
env-encoded residues are not required for transformation by p48v-myb.p48v-myb介导的转化不需要env编码的残基。
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引用本文的文献

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2
Cells transformed by a v-Myb-estrogen receptor fusion differentiate into multinucleated giant cells.由v-Myb-雌激素受体融合体转化的细胞分化为多核巨细胞。
J Virol. 1997 May;71(5):3760-6. doi: 10.1128/JVI.71.5.3760-3766.1997.
3
Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo.c-Myb首个重复序列的致癌性截短在体外和体内均会降低DNA结合能力。

本文引用的文献

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Morphological conversion of cell cultures by avian myeloblastosis virus.禽成髓细胞瘤病毒对细胞培养物的形态学转化
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J Virol. 1987 Oct;61(10):3284-7. doi: 10.1128/JVI.61.10.3284-3287.1987.
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DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation.与v-myb癌基因产物相关的DNA结合活性不足以引发转化。
J Virol. 1988 Nov;62(11):4398-402. doi: 10.1128/JVI.62.11.4398-4402.1988.
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Structural and functional domains of the myb oncogene: requirements for nuclear transport, myeloid transformation, and colony formation.myb癌基因的结构和功能结构域：核转运、髓系转化和集落形成的要求。
J Virol. 1988 Jun;62(6):1981-8. doi: 10.1128/JVI.62.6.1981-1988.1988.
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Specific amino acid substitutions are not required for transformation by v-myb of avian myeloblastosis virus.禽成髓细胞瘤病毒的v-myb基因进行转化并不需要特定的氨基酸替换。
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The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb.逆转录病毒转化基因v-myb的产物是细胞癌基因c-myb编码的蛋白质的截短版本。
Cell. 1983 Jun;33(2):345-55. doi: 10.1016/0092-8674(83)90416-6.
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Cell. 1982 Dec;31(2 Pt 1):453-63. doi: 10.1016/0092-8674(82)90138-6.
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