禽成髓细胞瘤病毒的v-myb基因进行转化并不需要特定的氨基酸替换。
Specific amino acid substitutions are not required for transformation by v-myb of avian myeloblastosis virus.
作者信息
Stober-Grässer U, Lipsick J S
机构信息
Department of Pathology, University of California, San Diego, La Jolla 92093.
出版信息
J Virol. 1988 Mar;62(3):1093-6. doi: 10.1128/JVI.62.3.1093-1096.1988.
Abstract
The protein product of the v-myb oncogene of avian myeloblastosis virus, p48v-myb, differs structurally in several ways from its normal cellular homolog, p75c-myb. We demonstrated that the 11 specific amino acid substitutions found in two independent molecular clones of this virus were not required for the transformation of myeloblasts by v-myb.
摘要
禽成髓细胞瘤病毒的v-myb癌基因的蛋白质产物p48v-myb在结构上与其正常细胞同源物p75c-myb在几个方面存在差异。我们证明，在该病毒的两个独立分子克隆中发现的11个特定氨基酸取代并非v-myb转化成髓细胞所必需。
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