a Environmental Physiology Lab , Department of Biomedical Sciences , University of Padova , Padua , Italy.
b CNR Institute of Bioimaging and Molecular Physiology , Segrate (Milano) , Italy.
J Enzyme Inhib Med Chem. 2018 Dec;33(1):1501-1505. doi: 10.1080/14756366.2018.1485149.
Early stages of avascular necrosis of the femoral head (AVNFH) can be conservatively treated with hyperbaric oxygen therapy (HBOT). This study investigated how HBOT modulates inflammatory markers and reactive oxygen species (ROS) in patients with AVNFH. Twenty-three male patients were treated with two cycles of HBOT, 30 sessions each with a 30 days break between cycles. Each session consisted of 90 minutes of 100% inspired oxygen at 2.5 absolute atmospheres of pressure. Plasma levels of tumor necrosis factor alfa (TNF-α), interleukin 6 (IL-6), interleukin 1 beta (IL-1β) and ROS production were measured before treatment (T0), after 15 and 30 HBOT sessions (T1 and T2), after the 30-day break (T3), and after 60 sessions (T4). Results showed a significant reduction in TNF-α and IL-6 plasma levels over time. This decrease in inflammatory markers mirrored observed reductions in bone marrow edema and reductions in patient self-reported pain.
早期股骨头缺血性坏死（AVNFH）可通过高压氧治疗（HBOT）进行保守治疗。本研究探讨了 HBOT 如何调节 AVNFH 患者的炎症标志物和活性氧（ROS）。23 名男性患者接受了两个周期的 HBOT 治疗，每个周期 30 次，两次治疗之间有 30 天的间隔。每个疗程包括 90 分钟的 100%吸氧，压力为 2.5 绝对大气压。在治疗前（T0）、15 次和 30 次 HBOT 治疗后（T1 和 T2）、30 天休息后（T3）和 60 次治疗后（T4）测量肿瘤坏死因子-α（TNF-α）、白细胞介素 6（IL-6）、白细胞介素 1β（IL-1β）和 ROS 产生的血浆水平。结果表明，随着时间的推移，TNF-α 和 IL-6 的血浆水平显著降低。这些炎症标志物的减少与骨髓水肿的观察减少和患者自我报告的疼痛减轻相一致。
