Li Hongyan, Wang Rong
Central Laboratory, Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Department of Liver Cancer Center, Beijing 302 Hospital, Beijing, China.
Brain Circ. 2017 Oct-Dec;3(4):199-203. doi: 10.4103/bc.bc_13_17. Epub 2017 Dec 29.
Alzheimer's disease (AD) is one of the most common and devastating aging-related neurodegenerative diseases. Besides the well-known role of chemokines and their receptors in the immune system, they are widely expressed in the nervous system, where they play roles in the regulation of cell migration and neurotransmission. The chemokine CXC motif receptor 4 (CXCR4) is evolutionarily highly conserved seven-transmembrane G-protein-coupled receptors (GPCRs). It has been demonstrated that CXCL12/CXCR4 signaling pathway involved in the pathologic process of AD. In this review, we demonstrated the GPCR family proteins and summarized the relationship between CXCR4 and GPCR, CXCR4 and AD. The review aimed to provide the novel insight of CXCR4 into the early prevention of mild cognitive impairment and in the diagnosis and treatment of AD.
阿尔茨海默病（AD）是最常见且极具破坏性的与衰老相关的神经退行性疾病之一。除了趋化因子及其受体在免疫系统中广为人知的作用外，它们还在神经系统中广泛表达，在其中发挥细胞迁移调节和神经传递的作用。趋化因子CXC基序受体4（CXCR4）是进化上高度保守的七跨膜G蛋白偶联受体（GPCR）。已经证明CXCL12/CXCR4信号通路参与了AD的病理过程。在本综述中，我们展示了GPCR家族蛋白，并总结了CXCR4与GPCR、CXCR4与AD之间的关系。本综述旨在为CXCR4在轻度认知障碍的早期预防以及AD的诊断和治疗方面提供新的见解。
