生物活性脂质与病理性视网膜血管生成。
Bioactive lipids and pathological retinal angiogenesis.
机构信息
Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Cellular Biology and Anatomy, MCG, Augusta University, Augusta, GA, USA.
出版信息
Br J Pharmacol. 2019 Jan;176(1):93-109. doi: 10.1111/bph.14507. Epub 2018 Nov 19.
Abstract
Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.
摘要
血管生成、视网膜屏障破坏、白细胞黏附和水肿是与视力丧失相关的增生性视网膜病变的主要特征。因此，确定调节这些血管功能障碍的因素对于靶向病理性血管生成至关重要。鉴于当前文献中报道的生物活性脂质的相互矛盾的作用，本综述的目的是为读者提供迄今为止在该领域所取得的成就的清晰路线图，特别关注多不饱和脂肪酸（PUFAs）衍生代谢物在增生性视网膜病变中的作用。这必然需要描述不同的视网膜细胞、血视网膜屏障以及（PUFAs）衍生代谢物在糖尿病性视网膜病变、早产儿视网膜病变和年龄相关性黄斑变性中的作用，因为它们是最常见的增生性视网膜病变类型。
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