Humboldt-Universität zu Berlin, Berlin, Germany.
Humboldt-Universität zu Berlin, Berlin, Germany.
Neurosci Biobehav Rev. 2018 Dec;95:280-314. doi: 10.1016/j.neubiorev.2018.09.021. Epub 2018 Sep 29.
The aim of this review is to summarize the current knowledge of associated features of co-occurring obsessive-compulsive disorder (OCD) and tic disorders (TD) and to critically evaluate hypotheses regarding the nature of their comorbidity.
We conducted a systematic review following PRISMA guidelines. To this aim, the PubMed, PsychInfo and ISI Web of Knowledge databases were searched up to August 30, 2018. For gender and age-of-onset we additionally conducted meta-analyses.
One hundred eighty-nine studies met inclusion criteria. We substantiate some acknowledged features and report evidence for differential biological mechanisms and treatment response. In general, studies were of limited methodological quality.
Several specific features are reliable associated with co-occurring OCD + TD. The field lacks methodological sound studies. The review found evidence against and in favor for different hypotheses regarding the nature of comorbidity of OCD and TD. This could indicate the existence of a stepwise model of co-morbidity, or could be an artefact of the low methodological quality of studies.
本综述旨在总结同时存在的强迫症（OCD）和抽动障碍（TD）相关特征的现有知识，并批判性地评估关于其共病性质的假说。
我们按照 PRISMA 指南进行了系统综述。为此，我们检索了 PubMed、PsychInfo 和 ISI Web of Knowledge 数据库，截至 2018 年 8 月 30 日。对于性别和发病年龄，我们还进行了荟萃分析。
有 189 项研究符合纳入标准。我们证实了一些公认的特征，并报告了证据表明存在不同的生物学机制和治疗反应。总的来说，这些研究的方法学质量有限。
同时存在 OCD 和 TD 存在几个可靠的特定相关特征。该领域缺乏方法学上健全的研究。本综述发现，关于 OCD 和 TD 共病性质的假说既有证据支持，也有证据反对。这可能表明共病存在一个逐步发展的模型，也可能是研究方法学质量低的人为因素。
