Rhodes R A, Tai H H, Chey W Y
Am J Dig Dis. 1978 Sep;23(9):833-9. doi: 10.1007/BF01079794.
Plasma secretin concentrations and pH in the second portion of duodenum were measured in the fasting state and during duodenal infusion of HCl in five patients with untreated celiac sprue, five celiac sprue patients after gluten-free diets, and five normal subjects. Mean fasting plasma secretin concentrations were insignificantly lower in untreated sprue patients (4.1 +/- 1.4 pg/ml) than in normal subjects (5.7 +/- 0.59 pg/ml). During 30-min intraduodenal infusions of 0.1 N HCl at 0.20 mEqH+/min, mean plasma secretin concentrations were significantly lower in untreated sprue patients (5.8 +/- 1.8 pg/ml) than in normal subjects (25.4 +/- 1.60 pg/ml, P less than 0.01). The increases in mean secretin concentrations over fasting were 2.1 +/- 0.82 pg/ml in untreated sprue patients compared to 19.7 +/- 1.47 pg/ml in normal subjects (P less than 0.01), a ninefold difference. The results indicate that endogenous release of secretin in response to duodenal acidification is impaired in patients with celiac sprue.
对5名未经治疗的乳糜泻患者、5名接受无麸质饮食后的乳糜泻患者以及5名正常受试者，在空腹状态下以及十二指肠输注盐酸期间，测量了十二指肠第二段的血浆促胰液素浓度和pH值。未经治疗的乳糜泻患者空腹时血浆促胰液素平均浓度（4.1±1.4 pg/ml）略低于正常受试者（5.7±0.59 pg/ml）。在以0.20 mEqH+/min的速度十二指肠内输注0.1 N盐酸30分钟期间，未经治疗的乳糜泻患者血浆促胰液素平均浓度（5.8±1.8 pg/ml）显著低于正常受试者（25.4±1.60 pg/ml，P<0.01）。未经治疗的乳糜泻患者促胰液素平均浓度较空腹时升高2.1±0.82 pg/ml，而正常受试者为19.7±1.47 pg/ml（P<0.01），相差9倍。结果表明，乳糜泻患者对十二指肠酸化的内源性促胰液素释放受损。
