Schaffalitzky de Muckadell O B, Fahrenkrug J, Rune S J
Scand J Gastroenterol. 1979;14(1):79-83. doi: 10.3109/00365527909179849.
In nine normal subjects intraduodenal pH was measured by means of a glass electrode placed in the passage from the first to the second part of the duodenum. The physiological variations in pH were simulated by intraduodenal injection of 2.5, 5, or 10 ml of 0.1 mol x 1(-1) HCl and subsequent neutralization by injection of bicarbonate. A total of 26 injections of acid was followed by a pH spike from a median pH of 7.0 to a median of pH 2.1 Median spike duration was 45 sec. The concentration of secretin in plasma increased from a median of 1.2 pmol x 1(-1) to a peak value of 2.2 pmol x 1(-1) after 4 min. It is concluded that the secretin response to a brief acidification of the first 4--6 cm of the duodenum is sufficient to explain the physiological variations in the concentration of secretin in human plasma.
在9名正常受试者中，通过将玻璃电极置于十二指肠第一部至第二部的通道中来测量十二指肠内pH值。通过十二指肠内注射2.5、5或10毫升0.1摩尔×1（-1）盐酸，随后注射碳酸氢盐进行中和，模拟pH值的生理变化。总共进行了26次酸注射，之后pH值从pH中位数7.0飙升至pH中位数2.1，中位数飙升持续时间为45秒。4分钟后，血浆中促胰液素浓度从1.2皮摩尔×1（-1）的中位数升至2.2皮摩尔×1（-1）的峰值。得出的结论是，十二指肠前4-6厘米短暂酸化引起的促胰液素反应足以解释人体血浆中促胰液素浓度的生理变化。
