Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Postgraduate Programme in Collective Health, Federal University of Maranhão, São Luís, MA, Brazil.
J Nutr Sci. 2024 Sep 18;13:e37. doi: 10.1017/jns.2024.39. eCollection 2024.
A gluten-free diet (GFD) may have a stronger potential impact on reducing cardiovascular (CV) risk factors, according to research evidence. We investigated the impact of GFD on CV risk variables by doing a systematic review and meta-analysis for this reason. We conducted a thorough database search starting on January 1, 2000, and ending on July 12, 2022. We used random-effects models to pool the data. Totally 19 articles met the eligible criteria and were included. Pooled findings indicated that intervention with GFD has a significantly beneficial effect on high-density lipoprotein (HDL) (WMD: 4.80 mg/dl, 95% CI: 2.09, 7.51, = 0.001), systolic blood pressure (SBP) (WMD: -2.96 mmHg; 95% CI: -4.11, -1.81, < 0.001), and C-reactive protein (CRP) (WMD: -0.40, mg/l, 95% CI: -0.67, -0.14, = 0.002) levels. In celiac patients as well as with an intervention duration of more than 48 weeks, GFD increased TC and HDL compared to non-celiac patients and with an intervention duration lower than 48 weeks, respectively. The results of the present study showed that GFD can have a significant and beneficial effect on HDL, SBP, and CRP.
由于研究证据表明，无麸质饮食（GFD）可能对降低心血管（CV）风险因素有更强的潜在影响。出于这个原因，我们进行了系统评价和荟萃分析，以研究 GFD 对 CV 风险变量的影响。我们从 2000 年 1 月 1 日开始进行了全面的数据库搜索，并于 2022 年 7 月 12 日结束。我们使用随机效应模型对数据进行汇总。共有 19 篇文章符合入选标准并被纳入。汇总结果表明，GFD 干预对高密度脂蛋白（HDL）（WMD：4.80mg/dl，95%CI：2.09，7.51， = 0.001）、收缩压（SBP）（WMD：-2.96mmHg；95%CI：-4.11，-1.81， < 0.001）和 C 反应蛋白（CRP）（WMD：-0.40mg/l，95%CI：-0.67，-0.14， = 0.002）水平有显著的有益影响。在乳糜泻患者以及干预持续时间超过 48 周的患者中，与非乳糜泻患者和干预持续时间低于 48 周的患者相比，GFD 增加了 TC 和 HDL。本研究的结果表明，GFD 可以对 HDL、SBP 和 CRP 产生显著且有益的影响。
