Sauer R
Fortschr Med. 1977 Sep 15;95(34):2081-3.
It was the aim of this study of document the influence of various dose rates on the CFU'S compartment. The information obtained should serve as a guideline to the design of radiotherapeutic programs with less hemopoietic toxicity in clinical radiation therapy. CBA mice were subjected to partial body X-ray irradiation from a linear accelerator (8MeV). The effect of dose rates of 6,70, 520 and 2800 R/min on CFU'S were studied in the irradiated and shielded marrow immediately after irradiation and 5,24 resp. 48 hours, 1 week and 3 weeks later. The following conclusions can be made: The reduction of CFU'S is significantly greater for low dose rates. After a dose of 150 R CFU'S reach normal values at 2 weeks, after 300 R at 3 weeks. With 450 R they are still subnormal at 3 weeks. A rebound phenomenon with increased CFU'S is seen at 3 weeks with 150 R and 300 R. An increase of CFU'S in shielded marrow is seen immediately after irradation. This increase is not dependent on the dose rate. The clinical implications of these findings are discussed.
本研究旨在记录不同剂量率对集落形成单位（CFU）区室的影响。所获得的信息应作为临床放射治疗中设计具有较低造血毒性的放射治疗方案的指导原则。将CBA小鼠置于直线加速器（8MeV）进行局部身体X射线照射。研究了照射后即刻以及照射后5小时、24小时、48小时、1周和3周时，6、70、520和2800R/分钟的剂量率对受照射和屏蔽骨髓中CFU的影响。可得出以下结论：低剂量率时CFU的减少明显更大。150R剂量后，CFU在2周时达到正常值，300R剂量后在3周时达到正常值。450R剂量时，3周时仍低于正常水平。150R和300R剂量时，3周时可见CFU增加的反弹现象。照射后即刻可见屏蔽骨髓中CFU增加。这种增加不依赖于剂量率。讨论了这些发现的临床意义。
