Zhu X Y, Wang W, Chen Y, Wang Y, Chen C, Lin P
The First Center Clinical College, Tianjin Medical University, Tianjin, 300192, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Sep;32(17):1325-1331. doi: 10.13201/j.issn.1001-1781.2018.17.008.
To compare the short-term and long-term curative effect and prognostic factors of 102 patients with sudden deafness.The clinical data of 102 patients with sudden deafness from 2012 to 2014 were analyzed retrospectively. Pure tone hearing thresholds were measured in patients with sudden deafness for 2 weeks after treatment and 3 to 5 years after discharge, in order to evaluate the short-term and long-term effects, and related prognostic factors were also compared.The short-term total effective rate of 102 patients with sudden deafness was 56.86%, and the long-term total effective rate was 69.61%.Under the same influence factors(female group, TG abnormal group,LDL abnormal group,HDL abnormality,blood rheology abnormality),the long-term total effective rate was greater than the short-term total effective rate(<0.05),the difference was statistically significant.Further analysis of the influencing factors of the prognosis of sudden deafness found that audiogram shapes, blood rheology and blood lipid(TC,LDL,HDL),age,were the same prognostic factors of sudden deafness. Different audiogram shapes,normal and abnormal hemorheology group,normal blood lipid group and abnormal group,the curative effect of different age groups,the difference which the results of each group were compared was significant(<0.05). However, there were differences between short-term and long-term prognostic factors.The short-term prognostic factors were also related to blood glucose and TG,the difference between normal blood glucose group and abnormal was significant(<0.05). The difference between the normal TG group and the abnormal group was compared,the difference was significant(<0.05).The long-term curative effect of sudden deafness was better than that of the short-term.
比较102例突发性聋患者的短期和长期疗效及预后因素。回顾性分析2012年至2014年102例突发性聋患者的临床资料。分别于治疗后2周及出院后3至5年测量突发性聋患者的纯音听阈，以评估短期和长期疗效，并比较相关预后因素。102例突发性聋患者的短期总有效率为56.86%，长期总有效率为69.61%。在相同影响因素（女性组、甘油三酯异常组、低密度脂蛋白异常组、高密度脂蛋白异常、血液流变学异常）下，长期总有效率大于短期总有效率（<0.05），差异有统计学意义。进一步分析突发性聋预后的影响因素发现，听力图类型、血液流变学及血脂（总胆固醇、低密度脂蛋白、高密度脂蛋白）、年龄，均为突发性聋的相同预后因素。不同听力图类型、血液流变学正常与异常组、血脂正常组与异常组、不同年龄组的疗效，各组结果比较差异有统计学意义（<0.05）。然而，短期和长期预后因素存在差异。短期预后因素还与血糖和甘油三酯有关，血糖正常组与异常组比较差异有统计学意义（<0.05）。甘油三酯正常组与异常组比较差异有统计学意义（<0.05）。突发性聋的长期疗效优于短期疗效。
