Ross Russell Amy L, Dryden Matthew S, Pinto Ashwin A, Lovett Joanna K
Neurology Department, Wessex Neurosciences Centre, Southampton General Hospital, Tremona Road, Southampton, UK
Department of Microbiology and Infection, Hampshire Hospitals NHS Foundation Trust & Rare and Imported Pathogens Department, PHE, Porton, Salisbury, UK.
Pract Neurol. 2018 Dec;18(6):455-464. doi: 10.1136/practneurol-2018-001998. Epub 2018 Oct 3.
Lyme disease (borreliosis) is a tick-borne bacterial infection caused by the spirochaete , transmitted by hard-backed ticks. Actual numbers of cases are increasing and it appears that the distribution across the UK is widening; however, it occurs most frequently in area of woodland, with temperate climate. It typically presents in mid to late summer. Lyme disease is a multisystem disease. The nervous system is the second most commonly affected system after the skin. Other systemic manifestations, such as carditis, keratitis, uveitis and inflammatory arthritis, rarely occur in European Lyme disease. In 2018, the National Institute for Health and Care Excellence has updated its guidelines on the diagnosis and management of Lyme disease. Here, we highlight important aspects of this guidance and provide a more detailed review of the clinical spectrum of neuroborreliosis, illustrated by cases we have seen.
莱姆病（疏螺旋体病）是一种由螺旋体引起的蜱传细菌感染，由硬蜱传播。实际病例数正在增加，而且在英国的分布似乎正在扩大；然而，它最常发生在气候温和的林地地区。它通常在夏中至夏末出现。莱姆病是一种多系统疾病。神经系统是仅次于皮肤的第二最常受影响的系统。其他全身表现，如心肌炎、角膜炎、葡萄膜炎和炎症性关节炎，在欧洲莱姆病中很少发生。2018年，英国国家卫生与临床优化研究所更新了其关于莱姆病诊断和管理的指南。在此，我们强调该指南的重要方面，并通过我们所见病例对神经莱姆病的临床谱进行更详细的综述。
