Enomoto Yui, Kimoto Akira, Suzuki Hiroaki, Nishiumi Shin, Yoshida Masaru, Komori Takahide
Department of Oral Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kobe J Med Sci. 2018 Sep 11;64(1):E26-E35.
This study aimed to explore novel metabolite biomarker candidates for screening oral squamous cell carcinoma (OSCC).
PATIENTS & METHODS: We collected plasma samples from 48 patients with OSCC and 29 with an oral disease and conducted a plasma metabolomics analysis of patients with OSCC using gas chromatography mass spectrometry. Then, we used the cross-validation procedure to ensure the accuracy of biomarker candidates.
We selected four biomarker candidates against OSCC. Their sensitivity was more than 90%, and the AUC was over 0.9 according to the receiver operating characteristic curve analysis.
The findings of this study suggest four potential metabolites as biomarkers for OSCC screening.
本研究旨在探索用于筛查口腔鳞状细胞癌（OSCC）的新型代谢物生物标志物候选物。
我们收集了48例OSCC患者和29例口腔疾病患者的血浆样本，并使用气相色谱 - 质谱联用技术对OSCC患者进行血浆代谢组学分析。然后，我们采用交叉验证程序来确保生物标志物候选物的准确性。
我们筛选出了四种针对OSCC的生物标志物候选物。根据受试者工作特征曲线分析，它们的敏感性超过90%，曲线下面积（AUC）超过0.9。
本研究结果表明四种潜在代谢物可作为OSCC筛查的生物标志物。
