Suvarna Vasanti, Sarkar Megha, Chaubey Pramila, Khan Tabassum, Sherje Atul, Patel Kavitkumar, Dravyakar Bhushan
SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.
Front Pharmacol. 2018 Sep 19;9:981. doi: 10.3389/fphar.2018.00981. eCollection 2018.
Bone metabolism involves a complex balance between matrix deposition, mineralization, and resorption. Numerous evidences have revealed that dietary components and phytoconstituents can influence these processes, through inhibition of bone resorption, thus exhibiting beneficial effects on the skeleton. Various traditional herbal formulae in ayurvedic and Chinese medicine have shown demonstrable benefits in pharmacological models of osteoporosis. The present review discusses normal bone metabolism and disorders caused by bone disruption, with particular reference to osteoporosis and current therapeutic treatment. Furthermore the effects of constituents from natural products on bone tissue are explained, with relevant evidences of efficacy in various experimental models.
骨代谢涉及基质沉积、矿化和吸收之间的复杂平衡。大量证据表明，膳食成分和植物成分可通过抑制骨吸收来影响这些过程，从而对骨骼产生有益影响。阿育吠陀医学和中医中的各种传统草药配方在骨质疏松症的药理模型中已显示出明显的益处。本综述讨论了正常骨代谢以及由骨破坏引起的疾病，尤其涉及骨质疏松症和当前的治疗方法。此外，还解释了天然产物成分对骨组织的影响，并列举了在各种实验模型中的相关疗效证据。
