Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Mol Med Rep. 2018 Jan;17(1):1493-1498. doi: 10.3892/mmr.2017.8036. Epub 2017 Nov 13.
Resveratrol is a non‑flavonoid polyphenol compound with a stilbene structure. As a type of phytoalexin produced under stress in plants, it improves the plant's resistance against pathogens and environment deterioration, and performs important functions beneficial to human health, such as anti‑cancer, anti‑oxidation, regulating blood lipid levels and prolonging life span. The effects of resveratrol were examined in a rat model of osteoarthritis (OA) and observed to ameliorate inflammatory damage and protect against OA. In the present study, resveratrol significantly inhibited the induction of clinical scores in rats with OA. Resveratrol inhibited tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6 and IL‑18 expression levels, and decreased caspase‑3/9 activity in rats with OA. Inducible nitric oxide synthase, nuclear factor (NF)‑κB, phosphorylated‑(p)‑AMP‑activated protein kinase and sirtuin 1 protein expression were significantly suppressed and heme oxygenase 1 (HO‑1) and nuclear factor erythroid 2‑related factor 2 (Nrf‑2) protein expression was stimulated in rats with OA treated with resveratrol. The current results indicate that resveratrol ameliorates inflammatory damage and protects against OA in a rat model of OA via NF‑κB and HO‑1/Nrf‑2 signaling.
白藜芦醇是一种非黄酮类多酚化合物，具有芪结构。作为植物在应激下产生的一种植物抗毒素，它可以提高植物对病原体和环境恶化的抵抗力，并发挥有益于人类健康的重要功能，如抗癌、抗氧化、调节血脂水平和延长寿命。本研究考察了白藜芦醇在骨关节炎（OA）大鼠模型中的作用，观察到其可改善炎症损伤并预防 OA。在本研究中，白藜芦醇显著抑制 OA 大鼠临床评分的诱导。白藜芦醇抑制肿瘤坏死因子-α、白细胞介素（IL）-1β、IL-6 和 IL-18 的表达水平，并降低 OA 大鼠中 caspase-3/9 的活性。诱导型一氧化氮合酶、核因子（NF）-κB、磷酸化（p）-AMP 激活蛋白激酶和 Sirtuin 1 蛋白表达显著受到抑制，而血红素加氧酶 1（HO-1）和核因子红细胞 2 相关因子 2（Nrf-2）蛋白表达在白藜芦醇处理的 OA 大鼠中受到刺激。目前的结果表明，白藜芦醇通过 NF-κB 和 HO-1/Nrf-2 信号通路改善炎症损伤并预防 OA 大鼠的 OA。
