Department of Ophthalmology, University Clinical Center, Medical University of Silesia in Katowice, 40-514 Katowice, Poland.
Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia in Katowice, 40-514 Katowice, Poland.
Nutrients. 2018 Oct 4;10(10):1423. doi: 10.3390/nu10101423.
Resveratrol is found in grapes, apples, blueberries, mulberries, peanuts, pistachios, plums and red wine. Resveratrol has been shown to possess antioxidative activity and a variety of preventive effects in models of many diseases. The aim of the study was to investigate if this substance may counteract the oxidative stress and polyol pathway in the lens of diabetic rats. The study was conducted on the rats with streptozotocin-induced type 1 diabetes. After the administration of resveratrol (10 and 20 mg/kg for 4 weeks), the oxidative stress markers in the lens were evaluated: activity of superoxide dismutase, catalase and glutathione peroxidase, as well as levels of total and soluble protein, level of glutathione, vitamin C, calcium, sulfhydryl group, advanced oxidation protein products, malonyldialdehyde, Total Oxidant Status and Total Antioxidant Reactivity. The obtained results indicate that the administration of resveratrol to the diabetic rats shows antioxidative properties. It is not a result of antiglycaemic activity but resveratrol probably directly affects the antioxidative system. Resveratrol did not affect the polyol pathway in the lens of diabetic rats. Our results may indirectly indicate benefits of consumption of foods as well as dietary supplements containing resveratrol in diminishing oxidative stress in lenses of individuals suffering from diabetes mellitus.
白藜芦醇存在于葡萄、苹果、蓝莓、桑椹、花生、开心果、李子和红酒中。白藜芦醇已被证明具有抗氧化活性和多种预防作用，可用于多种疾病的模型。本研究的目的是研究这种物质是否可以对抗糖尿病大鼠晶状体中的氧化应激和多元醇途径。该研究在链脲佐菌素诱导的 1 型糖尿病大鼠上进行。给予白藜芦醇（10 和 20mg/kg ，4 周）后，评估晶状体中的氧化应激标志物：超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶的活性，以及总蛋白和可溶性蛋白、谷胱甘肽、维生素 C、钙、巯基、高级氧化蛋白产物、丙二醛、总氧化剂状态和总抗氧化反应的水平。所得结果表明，向糖尿病大鼠给予白藜芦醇具有抗氧化特性。这不是抗糖活性的结果，而是白藜芦醇可能直接影响抗氧化系统。白藜芦醇对糖尿病大鼠晶状体中的多元醇途径没有影响。我们的结果可能间接地表明，食用含有白藜芦醇的食物以及膳食补充剂有助于减少糖尿病患者晶状体中的氧化应激。
