Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul 04763, Korea.
Department of Chemical Engineering, Kyung Hee University, Yongin 17104, Korea.
Int J Mol Sci. 2018 Oct 4;19(10):3025. doi: 10.3390/ijms19103025.
Electrical stimulation (ES) is known to affect the wound healing process by modulating skin cell behaviors. However, the conventional clinical devices that can generate ES for promoting wound healing require patient hospitalization due to large-scale of the extracorporeal devices. Herein, we introduce a disposable photovoltaic patch that can be applied to skin wound sites to control cellular microenvironment for promoting wound healing by generating ES. In vitro experiment results show that exogenous ES could enhance cell migration, proliferation, expression of extracellular matrix proteins, and myoblast differentiation of fibroblasts which are critical for wound healing. Our disposable photovoltaic patches were attached to the back of skin wound induced mice. Our patch successfully provided ES, generated by photovoltaic energy harvested from the organic solar cell under visible light illumination. In vivo experiment results show that the patch promoted cutaneous wound healing via enhanced host-inductive cell proliferation, cytokine secretion, and protein synthesis which is critical for wound healing process. Unlike the current treatments for wound healing that engage passive healing processes and often are unsuccessful, our wearable photovoltaic patch can stimulate regenerative activities of endogenous cells and actively contribute to the wound healing processes.
电刺激（ES）通过调节皮肤细胞行为来影响伤口愈合过程。然而，由于体外设备规模较大，能够产生 ES 以促进伤口愈合的传统临床设备需要患者住院治疗。在此，我们介绍了一种一次性的光伏贴片，可以应用于皮肤伤口部位，通过产生 ES 来控制细胞微环境以促进伤口愈合。体外实验结果表明，外源性 ES 可以增强细胞迁移、增殖、细胞外基质蛋白的表达和肌母细胞分化，这些都是伤口愈合的关键。我们的一次性光伏贴片被贴在诱导小鼠皮肤伤口的背部。我们的贴片成功地提供了 ES，这是通过有机太阳能电池在可见光照射下产生的光伏能量来实现的。体内实验结果表明，该贴片通过增强宿主诱导的细胞增殖、细胞因子分泌和蛋白质合成来促进皮肤伤口愈合，这些都是伤口愈合过程的关键。与目前主要通过被动愈合过程治疗伤口的方法不同，我们的可穿戴光伏贴片可以刺激内源性细胞的再生活动，并积极促进伤口愈合过程。
