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Analyzing the birth and propagation of two distinct prions, [PSI+] and [Het-s](y), in yeast.分析两种不同朊病毒[PSI+]和[Het-s](y)在酵母中的产生和传播。
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FEBS J. 2010 Mar;277(6):1359-68. doi: 10.1111/j.1742-4658.2010.07569.x. Epub 2010 Feb 9.
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Amyloids, prions and the inherent infectious nature of misfolded protein aggregates.淀粉样蛋白、朊病毒与错误折叠蛋白聚集体的内在感染性本质。
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The role of pre-existing aggregates in Hsp104-dependent polyglutamine aggregate formation and epigenetic change of yeast prions.预先存在的聚集体在酵母朊病毒的Hsp104依赖性多聚谷氨酰胺聚集体形成和表观遗传变化中的作用。
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Prion dynamics with size dependency-strain phenomena.具有尺寸依赖性-株现象的朊病毒动力学。
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A non-Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast.外来朊病毒[Het-s]的一个非富含Q/N的朊病毒结构域可作为朊病毒在酵母中传播。
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A structured model and likelihood approach to estimate yeast prion propagon replication rates and their asymmetric transmission.一种用于估计酵母朊病毒传播率及其非对称传递的结构化模型和似然方法。
PLoS Comput Biol. 2022 Jul 1;18(7):e1010107. doi: 10.1371/journal.pcbi.1010107. eCollection 2022 Jul.
2
A unifying model for the propagation of prion proteins in yeast brings insight into the [PSI+] prion.酵母朊病毒蛋白传播的统一模型为 [PSI+] 朊病毒提供了深入了解。
PLoS Comput Biol. 2020 May 26;16(5):e1007647. doi: 10.1371/journal.pcbi.1007647. eCollection 2020 May.

本文引用的文献

1
Kinetic models of guanidine hydrochloride-induced curing of the yeast [PSI+] prion.盐酸胍诱导酵母[PSI+]朊病毒固化的动力学模型。
J Theor Biol. 2011 Apr 7;274(1):1-11. doi: 10.1016/j.jtbi.2010.12.026. Epub 2010 Dec 22.
2
A size threshold limits prion transmission and establishes phenotypic diversity.尺寸阈值限制朊病毒的传播并建立表型多样性。
Science. 2010 Oct 29;330(6004):680-3. doi: 10.1126/science.1197785.
3
Prion dynamics and the quest for the genetic determinant in protein-only inheritance.朊病毒动力学与寻找仅蛋白质遗传中的遗传决定因素的探索。
Curr Opin Microbiol. 2009 Dec;12(6):623-30. doi: 10.1016/j.mib.2009.09.003. Epub 2009 Oct 26.
4
Aggregating knowledge about prions and amyloid.整合有关朊病毒和淀粉样蛋白的知识。
Cell. 2009 Apr 3;137(1):20-2. doi: 10.1016/j.cell.2009.03.030.
5
The number and transmission of [PSI] prion seeds (Propagons) in the yeast Saccharomyces cerevisiae.酿酒酵母中[PSI]朊病毒种子（传播子）的数量及传播
PLoS One. 2009;4(3):e4670. doi: 10.1371/journal.pone.0004670. Epub 2009 Mar 5.
6
Prions remodel gene expression in yeast.朊病毒重塑酵母中的基因表达。
Nat Cell Biol. 2009 Mar;11(3):241-3. doi: 10.1038/ncb0309-241.
7
Size distribution dependence of prion aggregates infectivity.朊病毒聚集体传染性的尺寸分布依赖性。
Math Biosci. 2009 Jan;217(1):88-99. doi: 10.1016/j.mbs.2008.10.007. Epub 2008 Nov 1.
8
Cell division modulates prion accumulation in cultured cells.细胞分裂调节培养细胞中的朊病毒积累。
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17971-6. doi: 10.1073/pnas.0708372104. Epub 2007 Nov 7.
9
Cell division is essential for elimination of the yeast [PSI+] prion by guanidine hydrochloride.细胞分裂对于通过盐酸胍消除酵母[PSI+]朊病毒至关重要。
Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11688-93. doi: 10.1073/pnas.0701392104. Epub 2007 Jul 2.
10
Hsp104-dependent remodeling of prion complexes mediates protein-only inheritance.热休克蛋白104（Hsp104）依赖的朊病毒复合物重塑介导仅蛋白质的遗传。
PLoS Biol. 2007 Feb;5(2):e24. doi: 10.1371/journal.pbio.0050024.

酵母朊病毒治愈曲线的离散时间分支过程模型

A Discrete-Time Branching Process Model of Yeast Prion Curing Curves.

作者信息

Sindi Suzanne S, Olofsson Peter

机构信息

Department of Mathematics, Trinity University.

Communicated by Peter Jagers and Christine Jacob.

出版信息

Math Popul Stud. 2013;20(1):1-13. doi: 10.1080/08898480.2013.748566. Epub 2013 Jan 27.

DOI:10.1080/08898480.2013.748566
PMID:30287982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6168217/
Abstract

The infectious agent of many neurodegenerative disorders is thought to be aggregates of prion protein, which are transmitted between cells. Recent work in yeast supports this hypothesis, but suggests that only aggregates below a critical size are transmitted efficiently. The total number of transmissible aggregates in a typical cell is a key determinant of strain infectivity. In a discrete-time branching process model of a yeast colony with prions, prion aggregates increase in size according to a Poisson process and only aggregates below a threshold size are transmitted during cell division. The total number of cells with aggregates in a growing population of yeast is expressed.

摘要

许多神经退行性疾病的致病因子被认为是朊病毒蛋白聚集体，它们在细胞间传播。酵母中的最新研究支持了这一假说，但表明只有低于临界大小的聚集体才能有效传播。典型细胞中可传播聚集体的总数是毒株传染性的关键决定因素。在一个含有朊病毒的酵母菌落的离散时间分支过程模型中，朊病毒聚集体的大小根据泊松过程增加，并且在细胞分裂期间只有低于阈值大小的聚集体才会传播。给出了不断增长的酵母群体中含有聚集体的细胞总数。