Shows T B, Eddy R L, Byers M G, Fukushima Y, Dehaven C R, Murray J C, Bell G I
Diabetes. 1987 Apr;36(4):546-9. doi: 10.2337/diab.36.4.546.
The glucose transporter is a membrane glycoprotein that is involved in the uptake of glucose by most, if not all, animal cells. A cloned cDNA that encodes the human protein was used to map the gene to a specific chromosomal region and to identify a DNA polymorphism. The human gene (designated GLUT) was assigned to chromosome 1p31.3----p35 by hybridization of the probe to DNA from a panel of human-mouse somatic cell hybrids containing different human chromosomes and by in situ hybridization to isolated metaphase chromosomes. The most likely location of GLUT is in 1p33. A common two-allele restriction-fragment-length polymorphism was identified with Xba I.
葡萄糖转运蛋白是一种膜糖蛋白，几乎所有动物细胞（即便不是全部）摄取葡萄糖的过程都与之有关。一个编码人类该蛋白的克隆cDNA被用于将该基因定位到特定的染色体区域，并识别一种DNA多态性。通过将探针与一组含有不同人类染色体的人-鼠体细胞杂种的DNA杂交，以及与分离的中期染色体进行原位杂交，人类基因（命名为GLUT）被定位到1p31.3----p35染色体上。GLUT最可能的位置是1p33。用Xba I鉴定出一种常见的双等位基因限制性片段长度多态性。
