Fentiman I S, Millis R R, Smith P, Ellul J P, Lampejo O
ICRF Clinical Oncology Unit, Guy's Hospital, London, UK.
Br J Cancer. 1997;75(7):1061-5. doi: 10.1038/bjc.1997.180.
In a series of 73 patients with mucoid breast carcinomas treated at Guy's Hospital between 1973 and 1989, 24 (33%) patients had pure mucoid lesions and 49 (67%) had mixed mucoid carcinomas. The patients with pure mucoid cancers had significantly smaller tumours and, among those in whom an axillary dissection was performed, mixed mucoid cancers were more likely to be associated with axillary nodal metastases (46% vs 14%). After long-term follow-up of 64 patients, both relapse-free and overall survival were significantly better for those with pure mucoid carcinomas, for whom the 10-year actuarial overall survival was 100%. The overall proportion of the tumour that was mucoid was also positively associated with a more favourable prognosis in patients with mixed tumours. With such a good prognosis, patients with pure mucoid carcinomas may not require systemic adjuvant therapy after adequate primary treatment.
在1973年至1989年间于盖伊医院接受治疗的73例黏液样乳腺癌患者中，24例（33%）为单纯黏液样病变，49例（67%）为黏液样混合癌。单纯黏液样癌患者的肿瘤明显较小，在进行腋窝清扫的患者中，黏液样混合癌更易伴有腋窝淋巴结转移（46% 对14%）。对64例患者进行长期随访后，单纯黏液样癌患者的无复发生存率和总生存率均显著更好，其10年精算总生存率为100%。在黏液样混合癌患者中，肿瘤黏液样成分的总体比例也与更良好的预后呈正相关。鉴于预后如此良好，单纯黏液样癌患者在充分的初始治疗后可能无需全身辅助治疗。
