变应原免疫治疗中的多方面 B 细胞反应。
The Multifaceted B Cell Response in Allergen Immunotherapy.
机构信息
Department of Biochemistry and Molecular Biology, Chemistry School, Complutense University, Madrid, Spain.
Department of Medicine Division of Rheumatology, Allergy, and Immunology, Department of Pediatrics, Division of Allergy and Immunology, Food Allergy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
出版信息
Curr Allergy Asthma Rep. 2018 Oct 5;18(12):66. doi: 10.1007/s11882-018-0819-1.
Abstract
While allergen immunotherapy (AIT) for IgE-mediated diseases holds curative potential, the considerable heterogeneity in clinical outcomes may relate to the complex mechanisms of tolerance. The regulation of humoral immunity by AIT contributes to the suppression of allergic responses. Recent findings have revealed novel roles for IgA and IgG antibodies in the induction of tolerance. These mechanisms synergize with their ability to block allergen-IgE binding and mediate inhibitory signaling of effector cells of the allergic response. In addition, the regulatory activity of B cells in AIT extends beyond IL-10 secretion and induction of IgG. Here, we review the evolution of the B cell response during AIT with special emphasis on the novel protective mechanisms entailing humoral immunity.
摘要
虽然变应原免疫治疗（AIT）对 IgE 介导的疾病具有潜在的治疗作用，但临床结果的显著异质性可能与耐受的复杂机制有关。AIT 对体液免疫的调节有助于抑制过敏反应。最近的研究发现，IgA 和 IgG 抗体在诱导耐受方面具有新的作用。这些机制与其阻断过敏原-IgE 结合和介导过敏反应效应细胞抑制信号的能力协同作用。此外，AIT 中 B 细胞的调节活性不仅局限于 IL-10 分泌和 IgG 的诱导。在这里，我们特别强调涉及体液免疫的新的保护机制，综述了 AIT 过程中 B 细胞反应的演变。
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