Division of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Spain.
Division of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, Santander, Spain.
Lipids Health Dis. 2020 Aug 29;19(1):200. doi: 10.1186/s12944-020-01377-6.
Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with several comorbidities and vascular risk factors, such as dyslipidemia. The present study aimed to assess the possible associations between the lipid profile and atherogenic indexes and the severity of HS.
This case-control study enrolled 78 HS patients and 62 healthy controls. Classic lipid profile and lipoprotein ratios, including the atherogenic index of plasma (AIP), were evaluated. The severity of HS was measured by the HS Physician Global Assessment (PGA).
HS-patients had lower serum total cholesterol and HDL-C levels and higher AIP than the control group. AIP was positively correlated to BMI, waist circumference, systolic and diastolic blood pressure, LDL-C, triglycerides, non-HDL-C, ApoB, HOMA, and hs-CRP and negatively to HDL-C and ApoA1. For the overall lipid profile, only AIP was related to a more severe HS (PGA ≥ 3) after controlling for age, sex, BMI, insulin resistance (IR), active smoking, and statin use (r = 0.268; p = 0.023). Multiple logistic regression adjusted for age, sex, BMI, IR, smoking status and statin use, showed that AIP ≥ 0.11 was significantly associated with the severity of HS (OR, 4.38; CI 95%, 1.09-17.50; p = 0.037).
In conclusion, these results showed that AIP is significantly and independently associated with HS severity.
化脓性汗腺炎（HS）是一种与多种合并症和血管危险因素相关的慢性炎症性疾病，例如血脂异常。本研究旨在评估血脂谱和致动脉粥样硬化指数与 HS 严重程度之间的可能相关性。
这项病例对照研究纳入了 78 例 HS 患者和 62 名健康对照者。评估了经典的血脂谱和脂蛋白比值，包括血浆致动脉粥样硬化指数（AIP）。HS 的严重程度通过 HS 医师总体评估（PGA）进行测量。
与对照组相比，HS 患者的血清总胆固醇和 HDL-C 水平较低，而 AIP 较高。AIP 与 BMI、腰围、收缩压和舒张压、LDL-C、甘油三酯、非 HDL-C、ApoB、HOMA 和 hs-CRP 呈正相关，与 HDL-C 和 ApoA1 呈负相关。对于整体血脂谱，仅 AIP 在控制年龄、性别、BMI、胰岛素抵抗（IR）、主动吸烟和他汀类药物使用后与更严重的 HS（PGA≥3）相关（r=0.268；p=0.023）。经年龄、性别、BMI、IR、吸烟状态和他汀类药物使用调整的多变量逻辑回归显示，AIP≥0.11 与 HS 的严重程度显著相关（OR，4.38；95%CI，1.09-17.50；p=0.037）。
总之，这些结果表明 AIP 与 HS 的严重程度显著相关且独立相关。
