一个转录但有缺陷的内源性逆转录病毒序列的3'长末端重复序列是一个有活性的转录启动子。
The 3' long terminal repeat of a transcribed yet defective endogenous retroviral sequence is a competent promoter of transcription.
作者信息
Levy D E, McKinnon R D, Brolaski M N, Gautsch J W, Wilson M C
出版信息
J Virol. 1987 Apr;61(4):1261-5. doi: 10.1128/JVI.61.4.1261-1265.1987.
Abstract
Although actively transcribed and present as multiple genomic copies, a distinct class of endogenous murine leukemia virus-related sequence does not give rise to infectious virus. Since the long terminal repeat at the 3' terminus provides the transcriptional start site after reintegration, we determined the structure and potential promoter activity of that sequence obtained from cDNA of endogenous retroviral transcripts. These studies demonstrate that the distinctive 3' long terminal repeat sequence of these transcripts could serve as an effective promoter of transcription and, therefore, may not be the primary defect in the infectious cycle of retroviral replication but may result in the propagation of these endogenous retroviral sequences in the genome as retrotransposons.
摘要
尽管一类独特的内源性鼠白血病病毒相关序列能被积极转录并以多个基因组拷贝形式存在，但其并不会产生感染性病毒。由于3'末端的长末端重复序列在重新整合后提供转录起始位点，我们确定了从内源性逆转录病毒转录本的cDNA中获得的该序列的结构和潜在启动子活性。这些研究表明，这些转录本独特的3'长末端重复序列可作为有效的转录启动子，因此，它可能不是逆转录病毒复制感染周期中的主要缺陷，而是可能导致这些内源性逆转录病毒序列作为逆转座子在基因组中传播。
相似文献
1
The 3' long terminal repeat of a transcribed yet defective endogenous retroviral sequence is a competent promoter of transcription.一个转录但有缺陷的内源性逆转录病毒序列的3'长末端重复序列是一个有活性的转录启动子。
J Virol. 1987 Apr;61(4):1261-5. doi: 10.1128/JVI.61.4.1261-1265.1987.
2
Carbon tetrachloride induction of rapid changes in liver nuclear protein factors capable of sequence-specific binding to regulatory elements in the long terminal repeat of polytropic-class endogenous murine leukemia virus-related proviruses.四氯化碳诱导肝脏核蛋白因子迅速发生变化，这些因子能够与多嗜性类内源性鼠白血病病毒相关前病毒长末端重复序列中的调控元件进行序列特异性结合。
Mol Carcinog. 1993;8(4):245-54. doi: 10.1002/mc.2940080407.
3
An array of murine leukemia virus-related elements is transmitted and expressed in a primate recipient of retroviral gene transfer.一系列与鼠白血病病毒相关的元件在逆转录病毒基因转移的灵长类受体中得以传播并表达。
J Virol. 1996 Feb;70(2):887-97. doi: 10.1128/JVI.70.2.887-897.1996.
4
Replication-competent and -defective retrovirus vectors for oncogenic studies.用于致癌研究的具有复制能力和缺陷的逆转录病毒载体。
Methods Enzymol. 1995;254:206-28. doi: 10.1016/0076-6879(95)54016-4.
5
Injury-associated induction of two novel and replication-defective murine retroviral RNAs in the liver of mice.小鼠肝脏中与损伤相关的两种新型且复制缺陷型鼠逆转录病毒RNA的诱导。
Virus Res. 2003 Jun;93(2):189-98. doi: 10.1016/s0168-1702(03)00097-2.
6
Negative regulatory element associated with potentially functional promoter and enhancer elements in the long terminal repeats of endogenous murine leukemia virus-related proviral sequences.与内源性鼠白血病病毒相关前病毒序列长末端重复序列中潜在功能性启动子和增强子元件相关的负调控元件。
J Virol. 1989 Jun;63(6):2746-57. doi: 10.1128/JVI.63.6.2746-2757.1989.
7
Normal expression of polymorphic endogenous retroviral RNA containing segments identical to mink cell focus-forming virus.含有与水貂细胞融合形成病毒相同片段的多态性内源性逆转录病毒RNA的正常表达。
J Virol. 1985 Dec;56(3):691-700. doi: 10.1128/JVI.56.3.691-700.1985.
8
Transcriptional initiation and postinitiation effects of murine leukemia virus long terminal repeat R-region sequences.小鼠白血病病毒长末端重复序列R区序列的转录起始和起始后效应
J Virol. 1991 Dec;65(12):6961-8. doi: 10.1128/JVI.65.12.6961-6968.1991.
9
Scheme for the generation of a truncated endogenous murine leukaemia virus, the Fv-4 resistance gene.
J Gen Virol. 1992 Aug;73 ( Pt 8):1925-30. doi: 10.1099/0022-1317-73-8-1925.
10
A murine leukemia virus derived retroviral vector with a rat VL30 packaging psi sequence.一种带有大鼠VL30包装ψ序列的源自鼠白血病病毒的逆转录病毒载体。
Bone Marrow Transplant. 1992;9 Suppl 1:143-7.
引用本文的文献
1
Recombinant Origins of Pathogenic and Nonpathogenic Mouse Gammaretroviruses with Polytropic Host Range.具有多嗜性宿主范围的致病性和非致病性小鼠γ逆转录病毒的重组起源
J Virol. 2017 Oct 13;91(21). doi: 10.1128/JVI.00855-17. Print 2017 Nov 1.
2
Origins of the endogenous and infectious laboratory mouse gammaretroviruses.内源性和感染性实验室小鼠γ逆转录病毒的起源。
Viruses. 2014 Dec 26;7(1):1-26. doi: 10.3390/v7010001.
3
Endogenous gammaretrovirus acquisition in Mus musculus subspecies carrying functional variants of the XPR1 virus receptor.内源性γ逆转录病毒在携带 XPR1 病毒受体功能变体的 Mus musculus 亚种中的获得。
J Virol. 2013 Sep;87(17):9845-55. doi: 10.1128/JVI.01264-13. Epub 2013 Jul 3.
4
Multiple endogenous xenotropic and mink cell focus-forming murine leukemia virus-related transcripts are induced by polyclonal immune activators.多克隆免疫激活剂可诱导多种内源性嗜异性和貂细胞集落形成的鼠白血病病毒相关转录本。
J Virol. 1988 Oct;62(10):3545-50. doi: 10.1128/JVI.62.10.3545-3550.1988.
5
Truncated gag products encoded by Gv-1-responsive endogenous retrovirus loci.由Gv-1反应性内源性逆转录病毒基因座编码的截短型gag产物。
J Virol. 1989 Oct;63(10):4136-47. doi: 10.1128/JVI.63.10.4136-4147.1989.
6
Negative regulatory element associated with potentially functional promoter and enhancer elements in the long terminal repeats of endogenous murine leukemia virus-related proviral sequences.与内源性鼠白血病病毒相关前病毒序列长末端重复序列中潜在功能性启动子和增强子元件相关的负调控元件。
J Virol. 1989 Jun;63(6):2746-57. doi: 10.1128/JVI.63.6.2746-2757.1989.
本文引用的文献
1
Silent infection of murine embryonal carcinoma cells by Moloney murine leukemia virus.莫洛尼鼠白血病病毒对小鼠胚胎癌细胞的潜伏感染
Virology. 1980 Aug;105(1):241-4. doi: 10.1016/0042-6822(80)90171-3.
2
Analysis of the env gene of a molecularly cloned and biologically active Moloney mink cell focus-forming proviral DNA.对分子克隆且具有生物活性的莫洛尼貂细胞病灶形成前病毒DNA的env基因进行分析。
J Virol. 1982 Oct;44(1):19-31. doi: 10.1128/JVI.44.1.19-31.1982.
3
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.在哺乳动物细胞中表达氯霉素乙酰转移酶的重组基因组。
Mol Cell Biol. 1982 Sep;2(9):1044-51. doi: 10.1128/mcb.2.9.1044-1051.1982.
4
Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein.弗氏脾脏集落形成前病毒感染性克隆的完整核苷酸序列：gp55是一种包膜融合糖蛋白。
Proc Natl Acad Sci U S A. 1983 Aug;80(16):5037-41. doi: 10.1073/pnas.80.16.5037.
5
Evidence for mobility of a new family of mouse middle repetitive DNA elements (LTR-IS).小鼠中间重复DNA元件新家族（LTR-IS）移动性的证据。
Nucleic Acids Res. 1984 Apr 25;12(8):3603-10. doi: 10.1093/nar/12.8.3603.
6
Nucleotide sequence analysis establishes the role of endogenous murine leukemia virus DNA segments in formation of recombinant mink cell focus-forming murine leukemia viruses.核苷酸序列分析确定了内源性鼠白血病病毒DNA片段在重组水貂细胞灶形成性鼠白血病病毒形成中的作用。
J Virol. 1984 Jun;50(3):864-71. doi: 10.1128/JVI.50.3.864-871.1984.
7
Characterization of the env gene and long terminal repeat of molecularly cloned Friend mink cell focus-inducing virus DNA.分子克隆的Friend水貂细胞灶性诱导病毒DNA的env基因和长末端重复序列的特征分析
J Virol. 1984 Jun;50(3):813-21. doi: 10.1128/JVI.50.3.813-821.1984.
8
Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells.莫洛尼鼠白血病病毒调控序列在F9胚胎癌细胞中的无功能状态
Nature. 1984;308(5958):470-2. doi: 10.1038/308470a0.
9
Nucleotide sequences of the retroviral long terminal repeats and their adjacent regions.逆转录病毒长末端重复序列及其相邻区域的核苷酸序列。
Nucleic Acids Res. 1984 Feb 24;12(4):1767-78. doi: 10.1093/nar/12.4.1767.
10
Molecular analysis of the envelope gene and long terminal repeat of Friend mink cell focus-inducing virus: implications for the functions of these sequences.弗氏貂细胞灶性诱导病毒包膜基因和长末端重复序列的分子分析：这些序列功能的启示
J Virol. 1984 Mar;49(3):828-40. doi: 10.1128/JVI.49.3.828-840.1984.
Zotero 插件