肝靶向治疗在转移性结直肠癌中的作用
The Role of Liver-Directed Therapy in Metastatic Colorectal Cancer.
作者信息
Tan Hon Lyn, Lee Matilda, Vellayappan Balamurugan A, Neo Wee Thong, Yong Wei Peng
机构信息
Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS), National University Health System, 1E Kent Ridge Road, Singapore, 119228 Singapore.
Department of Radiation Oncology, National University Cancer Institute, Singapore (NCIS), National University Health System, 1E Kent Ridge Road, Singapore, 119228 Singapore.
出版信息
Curr Colorectal Cancer Rep. 2018;14(5):129-137. doi: 10.1007/s11888-018-0409-6. Epub 2018 Sep 13.
PURPOSE OF REVIEW
Colorectal cancer liver metastasis is a major clinical problem, and surgical resection is the only potentially curative treatment. We seek to discuss various liver-directed therapy modalities and explore their roles in the evolving realm of treatment strategies for metastatic colorectal cancer.
RECENT FINDINGS
Clinical outcomes for patients with colorectal cancer liver metastases have improved as more patients undergo potentially curative resection and as the armamentarium of systemic treatment and liver-directed therapies continues to expand. Liver-directed therapies have been developed as adjuncts to improve resectability, employed in the adjuvant setting to potentially reduce local recurrence rates, and utilized in the palliative setting with the aim to improve overall survival.
SUMMARY
Ongoing research is expected to validate the role of these evolving therapeutic options, and determine how best to sequence and when to apply these therapies.
综述目的
结直肠癌肝转移是一个主要的临床问题，手术切除是唯一可能治愈的治疗方法。我们旨在讨论各种肝脏定向治疗方式，并探讨它们在转移性结直肠癌治疗策略不断发展的领域中的作用。
最新发现
随着越来越多的患者接受可能治愈的切除术，以及全身治疗和肝脏定向治疗手段的不断扩展，结直肠癌肝转移患者的临床结局有所改善。肝脏定向治疗已被开发为辅助手段以提高可切除性，用于辅助治疗以潜在降低局部复发率，并用于姑息治疗以提高总生存率。
总结
正在进行的研究有望验证这些不断发展的治疗选择的作用，并确定如何最佳地安排这些治疗的顺序以及何时应用这些治疗。
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