慢性肝病中肝性脑病的发病机制
Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease.
作者信息
Ochoa-Sanchez Rafael, Rose Christopher F
机构信息
Hepato-Neuro Laboratory, CRCHUM, Université de Montréal, Montréal, Québec, H2X 0A9, Canada.
出版信息
J Clin Exp Hepatol. 2018 Sep;8(3):262-271. doi: 10.1016/j.jceh.2018.08.001. Epub 2018 Aug 18.
Abstract
Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that occurs during chronic liver disease (CLD). While ammonia and other precipitating factors in liver disease including inflammation, bile acids, oxidative stress, and lactate play a role in the pathogenesis of HE, the exact mechanism that leads to HE is not fully understood. Notably, accumulating evidence points toward a synergic effect rather than independent actions among precipitating factors that contributes to the development and severity of HE in CLD. Hence, this review is aimed to briefly discuss the single and synergic interplay of pathological factors in the progression and severity of HE.
摘要
肝性脑病（HE）是一种在慢性肝病（CLD）期间出现的复杂神经精神综合征。虽然肝病中的氨和其他促发因素，包括炎症、胆汁酸、氧化应激和乳酸，在HE的发病机制中起作用，但导致HE的确切机制尚未完全明确。值得注意的是，越来越多的证据表明，促发因素之间存在协同作用而非独立作用，这有助于CLD中HE的发生和严重程度。因此，本综述旨在简要讨论病理因素在HE进展和严重程度中的单一和协同相互作用。
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