Zhang X K, Huang D P, Chiu D K, Chiu J F
Biochem Biophys Res Commun. 1987 Feb 13;142(3):932-8. doi: 10.1016/0006-291x(87)91503-8.
Oncogene expression was examined in the human fetal liver and human hepatomas. Erb (B), erb (A+B), Ha-ras, myc, fos and fms oncogene expression elevated in certain stages of fetal liver development and in hepatoma as compared to the normal adult human liver. In contrast, rel, src, mos, sis, myb, Ki-ras and bas oncogenes showed no apparent change of their mRNA levels during fetal liver development and in hepatoma. Further study of erb B oncogene expression in human cirrhotic liver and hepatoma demonstrated a strong correlation between erb B expression and alteration of its gene structure.
对人胎肝和肝癌中的癌基因表达进行了检测。与正常成人肝脏相比，Erb (B)、erb (A+B)、Ha-ras、myc、fos和fms癌基因表达在胎肝发育的某些阶段以及肝癌中有所升高。相比之下，rel、src、mos、sis、myb、Ki-ras和bas癌基因在胎肝发育过程和肝癌中其mRNA水平没有明显变化。对人肝硬化肝脏和肝癌中erb B癌基因表达的进一步研究表明，erb B表达与其基因结构改变之间存在很强的相关性。
