Yamamoto N, Harada S, Nakashima H
AIDS Res. 1986 Dec;2 Suppl 1:S183-9.
The effects of various compounds were studied quantitatively on the growth of human immunodeficiency virus (HIV). For this we used a human T-cell leukemia virus type I carrying cell line, MT-4 which is most permissive for HIV infection. The results are summarized as follows: 1) Prostaglandin E2 and 12-0-tetradecanoylphorbol-13-acetate enhanced the production of HIV significantly in MT-4 cells as well as a continuous HIV producer Molt-4/HTLV-III cells. 2) Interferon gamma, retinoic acid and 3'-azido-3'-deoxythymidine inhibited the replication of HIV at the concentrations which were not cytotoxic. Mechanism of action of these compounds and its clinical implications are discussed.
定量研究了各种化合物对人类免疫缺陷病毒（HIV）生长的影响。为此，我们使用了携带I型人类T细胞白血病病毒的细胞系MT-4，该细胞系对HIV感染最为敏感。结果总结如下：1）前列腺素E2和12-O-十四烷酰佛波醇-13-乙酸酯在MT-4细胞以及持续产生HIV的Molt-4/HTLV-III细胞中显著增强了HIV的产生。2）γ干扰素、视黄酸和3'-叠氮-3'-脱氧胸苷在无细胞毒性的浓度下抑制了HIV的复制。讨论了这些化合物的作用机制及其临床意义。
