Ohtsuka N, Konno T, Miyauchi Y, Maeda H
Cancer. 1987 May 1;59(9):1560-5. doi: 10.1002/1097-0142(19870501)59:9<1560::aid-cncr2820590905>3.0.co;2-j.
A new method of arterially administering an oily anticancer agent was successfully established for the selective targeting of metastatic lymph nodes. A high molecular weight anticancer agent, a conjugate of copolymer (styrene maleic acid) to neocarzinostatin (SMANCS) was prepared in our laboratory and dissolved in a lymphographic oily contrast medium, Lipiodol (SMANCS/Lipiodol). SMANCS/Lipiodol was administered intraoperatively to eight patients with colorectal cancer and preoperatively to one patient with gastric cancer with lymph node metastases. In six of the patients with colorectal cancer, the drug was administered via an artery and in the other two patients the drug was injected into the wall of the colon near the primary cancer. In the patient with gastric cancer, the drug was administered via the left gastric artery. Delivery of the drug to the lymph nodes was examined roentgenologically and the anticancer effect was examined histologically. The results showed that SMANCS/Lipiodol could be delivered to the metastatic lymph node via the artery, but it could not be delivered to the metastatic lesion of the lymph node via the lymphatic route. In the patient with gastric cancer, SMANCS/Lipiodol preoperatively administered via an artery was found to remain selectively in a metastatic lymph node and an anticancer effect was histologically proved in all three of the metastatic lymph nodes.
一种用于转移性淋巴结选择性靶向的动脉内给予油性抗癌剂的新方法已成功建立。我们实验室制备了一种高分子量抗癌剂，即共聚物（苯乙烯马来酸）与新制癌菌素（SMANCS）的结合物，并将其溶解于淋巴造影油性造影剂碘油中（SMANCS/碘油）。对8例结直肠癌患者在术中给予SMANCS/碘油，对1例伴有淋巴结转移的胃癌患者在术前给予。在6例结直肠癌患者中，药物通过动脉给药，另外2例患者将药物注射到原发癌附近的结肠壁。在胃癌患者中，药物通过胃左动脉给药。通过放射学检查药物向淋巴结的递送情况，并通过组织学检查抗癌效果。结果表明，SMANCS/碘油可通过动脉递送至转移性淋巴结，但不能通过淋巴途径递送至淋巴结的转移病灶。在胃癌患者中，术前通过动脉给予的SMANCS/碘油被发现选择性地保留在一个转移性淋巴结中，并且在所有三个转移性淋巴结中均通过组织学证实有抗癌作用。
