Sparks Courtney R, Gorney Angela, Williams Kim, Griffith Emily H, Cerda-Gonzalez Sofia, Lascelles B Duncan X, Olby Natasha J
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.
Department of Statistics, North Carolina State University, Raleigh, North Carolina.
J Vet Intern Med. 2018 Nov;32(6):2021-2028. doi: 10.1111/jvim.15297. Epub 2018 Oct 11.
Cavalier King Charles Spaniels (CKCS) suffer pain associated with Chiari-like malformation and syringomyelia (CMSM). People suffer from a similar condition and describe numerous sensory abnormalities. Sensory changes have not been quantified in affected CKCS.
To use quantitative sensory testing (QST) to quantify thermal and mechanical thresholds in CKCS and to compare QST in dogs with and without syringomyelia (SM).
Forty-four CKCS.
Prospective study. Dogs underwent neurological examinations and craniocervical magnetic resonance imaging (MRI). Thermal testing was performed over the humerus and thorax (n = 32); mechanical testing was performed on the paw and neck (n = 44). Latencies, thresholds, and response rates were compared with presence and severity of SM on MRI, presence of pain reported by the owner and pain identified on examination.
Thirty dogs had SM, 30 were painful on examination, 29 were owner-reported symptomatic. Thermal and mechanical variables were not significantly different based on presence or severity of SM. Dogs with pain on examination had decreased mechanical thresholds on the paw (0.38 kg, SD = 0.18) and neck (2.05 kg, SD = 0.74) compared to thresholds of dogs without pain on examination on the paw (0.60 kg, SD = 0.30) and neck (2.72 kg, SD = 0.57; P = .021).
Mechanical and thermal sensitivity does not appear to be related to the presence of SM, but mechanical sensitivity appears to be related to the presence of pain and clinical signs. Mechanical testing may be useful for assessing sensory abnormalities during clinical trials.
骑士查理王小猎犬（CKCS）会遭受与 Chiari 样畸形和脊髓空洞症（CMSM）相关的疼痛。人类也患有类似病症，并描述了许多感觉异常情况。但尚未对受影响的 CKCS 的感觉变化进行量化。
使用定量感觉测试（QST）来量化 CKCS 的热阈值和机械阈值，并比较患有和未患有脊髓空洞症（SM）的犬的 QST。
44 只 CKCS。
前瞻性研究。对犬进行神经学检查和颅颈磁共振成像（MRI）。在肱骨和胸部进行热测试（n = 32）；在爪子和颈部进行机械测试（n = 44）。将潜伏期、阈值和反应率与 MRI 上 SM 的存在和严重程度、主人报告的疼痛情况以及检查中发现的疼痛进行比较。
30 只犬患有 SM，30 只在检查时疼痛，29 只主人报告有症状。基于 SM 的存在或严重程度，热和机械变量无显著差异。与检查时无疼痛的犬相比，检查时有疼痛的犬爪子的机械阈值（0.38 千克，标准差 = 0.18）和颈部的机械阈值（2.05 千克，标准差 = 0.74）降低，而检查时无疼痛的犬爪子的机械阈值为（0.60 千克，标准差 = 0.30），颈部为（2.72 千克，标准差 = 0.57；P = 0.021）。
机械和热敏感性似乎与 SM 的存在无关，但机械敏感性似乎与疼痛和临床体征的存在有关。机械测试可能有助于在临床试验中评估感觉异常。
