Divisions of Cardiology and Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States.
Divisions of Cardiology and Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States.
Trends Cardiovasc Med. 2019 Jul;29(5):285-295. doi: 10.1016/j.tcm.2018.09.005. Epub 2018 Sep 20.
Although amiodarone is considered the most effective antiarrhythmic agent, its use is limited by a wide variety of potential toxicities. The purpose of this review is to provide a comprehensive "bench to bedside" overview of the ways amiodarone influences thyroid function. We performed a systematic search of MEDLINE to identify peer-reviewed clinical trials, randomized controlled trials, meta-analyses, and other clinically relevant studies. The search was limited to English-language reports published between 1950 and 2017. Amiodarone was searched using the terms adverse effects, hypothyroidism, myxedema, hyperthyroidism, thyroid storm, atrial fibrillation, ventricular arrhythmia, and electrical storm. Google and Google scholar as well as bibliographies of identified articles were reviewed for additional references. We included 163 germane references in this review. Because amiodarone is one of the most frequently prescribed antiarrhythmic drugs in the United States, the mechanistic, diagnostic and therapeutic information provided is relevant for practicing clinicians in a wide range of medical specialties.
虽然胺碘酮被认为是最有效的抗心律失常药物，但由于其具有多种潜在毒性，其应用受到限制。本文的目的是提供一个全面的“从基础到临床”的胺碘酮对甲状腺功能影响的综述。我们对 MEDLINE 进行了系统的检索，以确定同行评议的临床试验、随机对照试验、荟萃分析和其他临床相关研究。检索仅限于 1950 年至 2017 年期间以英文发表的报告。胺碘酮的检索使用了不良反应、甲状腺功能减退症、黏液性水肿、甲状腺功能亢进症、甲状腺危象、心房颤动、室性心律失常和电风暴等术语。此外，还查阅了已确定文章的参考文献和 Google 及 Google Scholar，以获取更多的参考文献。本文综述共纳入了 163 篇相关文献。由于胺碘酮是美国最常开的抗心律失常药物之一，因此提供的关于其作用机制、诊断和治疗的信息与广泛医学专业的临床医生密切相关。
