Gao Jing, Yang Shuna, Wang Kun, Zhong Qianwei, Ma Aijun, Pan Xudong
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
J Stroke Cerebrovasc Dis. 2019 Jan;28(1):38-43. doi: 10.1016/j.jstrokecerebrovasdis.2018.09.008. Epub 2018 Oct 9.
Cerebral atherosclerosis is the most important mechanism for ischemic stroke. However, specific plasma biomarkers to assess atherosclerosis susceptibility are still lacking. Circulating miRNAs have been shown to be promising biomarkers for various pathologic conditions. We investigated whether plasma miR-126 and miR-143 could be used as biomarkers for identifying and evaluating cerebral atherosclerosis. Results showed that miR-143 and miR-126 might participate in the process of atherosclerosis and were minimally affected by cerebral infarction. Using Pearson correlation analysis, we showed that miR-126 and miR-143 were correlated with the presence and severity of cerebral atherosclerosis. The ability of miR-126 and miR-143 to differentiate atherosclerosis patients from healthy controls was demonstrated via a receiving operating characteristic curve with high specificity and sensitivity. Our data thus indicate that miR-126 and miR-143 may be potential specific biomarkers for atherosclerosis.
脑动脉粥样硬化是缺血性中风最重要的机制。然而，目前仍缺乏用于评估动脉粥样硬化易感性的特异性血浆生物标志物。循环中的微小RNA（miRNA）已被证明是各种病理状况下很有前景的生物标志物。我们研究了血浆miR - 126和miR - 143是否可作为识别和评估脑动脉粥样硬化的生物标志物。结果显示，miR - 143和miR - 126可能参与动脉粥样硬化过程，且受脑梗死影响极小。通过Pearson相关性分析，我们发现miR - 126和miR - 143与脑动脉粥样硬化的存在及严重程度相关。通过具有高特异性和敏感性的受试者工作特征曲线，证明了miR - 126和miR - 143区分动脉粥样硬化患者与健康对照的能力。因此，我们的数据表明miR - 126和miR - 143可能是动脉粥样硬化潜在的特异性生物标志物。
