Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.
Malawi Public Health Forum, Lilongwe, Malawi.
BMJ Open. 2018 Oct 10;8(10):e022949. doi: 10.1136/bmjopen-2018-022949.
Measures of epidemiological burdens are an important contribution to estimating disease severity and determining the at-risk populations for seasonal influenza. In the absence of these data, it is extremely difficult for policy-makers to decide on how to distribute limited resources. This systematic review will synthesise the literature on reported burden of seasonal influenza (eg, morbidity and mortality) in sub-Saharan Africa.
We will include published epidemiological studies that capture the burden estimation of seasonal influenza between 1 January 2000 and 31 August 2018. Studies that have reported disease burden estimates associated to influenza-like illness, acute respiratory illness, acute lower respiratory illness, severe acute respiratory illness and severe or very severe pneumonia using laboratory-confirmed influenza cases will be included. We will perform a multiple electronic database search in PubMed, Embase, African Journals Online, Cochrane, Web of science, CINAHL and Google scholar for eligible studies. The reference lists of relevant studies will also be hand-searched for potentially eligible studies. The titles and abstracts of identified records will be screened independently by two authors. The full-text articles of potentially eligible studies will be assessed independently by two authors. Discrepancies will be resolved by discussion, and by a third author if the first two authors fail to come to a consensus. The measures of the burden of influenza will be aggregated using a meta-analysis for homogeneous studies and narrative synthesis if the studies are heterogeneous. The strength of the evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation approach.
This systematic review will use publicly available data; and as such, no formal ethical review is required. Our findings will be published in a peer-reviewed journal and also disseminated through conferences and stakeholder meetings.
CRD42017074091.
衡量流行病学负担是评估疾病严重程度和确定季节性流感高危人群的重要贡献。如果没有这些数据，决策者很难决定如何分配有限的资源。本系统评价将综合分析撒哈拉以南非洲地区季节性流感（如发病率和死亡率）报告负担的文献。
我们将纳入 2000 年 1 月 1 日至 2018 年 8 月 31 日期间发表的具有季节性流感负担评估的流行病学研究。使用实验室确诊流感病例报告流感样疾病、急性呼吸道疾病、急性下呼吸道疾病、严重急性呼吸道疾病和严重或非常严重肺炎的疾病负担估计的研究将被纳入。我们将在 PubMed、Embase、African Journals Online、Cochrane、Web of Science、CINAHL 和 Google Scholar 中进行多次电子数据库检索，以寻找符合条件的研究。还将对相关研究的参考文献进行手工检索，以寻找可能符合条件的研究。由两名作者独立筛选确定记录的标题和摘要。如果两名作者存在分歧，则通过讨论或第三名作者解决。对于同质研究，将使用荟萃分析汇总流感负担的衡量标准；如果研究存在异质性，则采用叙述性综合。使用推荐评估、制定和评估方法评估证据的强度。
本系统评价将使用公开可用的数据，因此不需要正式的伦理审查。我们的研究结果将发表在同行评议的期刊上，并通过会议和利益攸关方会议进行传播。
PROSPERO 注册号：CRD42017074091。
