Department of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montréal, Québec, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Ann Work Expo Health. 2019 Jan 7;63(1):22-33. doi: 10.1093/annweh/wxy083.
OBJECTIVES: The CANJEM general population job-exposure matrix summarizes expert evaluations of 31 673 jobs from four population-based case-control studies of cancer conducted in Montreal, Canada. Intensity in each CANJEM cell is represented as relative distributions of the ordinal (low, medium, high) ratings of jobs assigned by the experts. We aimed to apply quantitative concentrations to CANJEM cells using Canadian historical measurements from the Canadian Workplace Exposure Database (CWED), taking exposure to wood dust as an example. METHODS: We selected 5170 personal and area wood dust measurements from 31 occupations (2011 Canadian National Occupational Classification) with a non-zero exposure probability in CANJEM between 1930 and 2005. The measurements were taken between 1981 and 2003 (median 1989). A Bayesian hierarchical model was applied to the wood dust concentrations with occupations as random effects, and sampling duration, year, sample type (area or personal), province, and the relative proportion of jobs exposed at medium and high intensity in CANJEM cells as fixed effects. RESULTS: The estimated geometric mean (GM) concentrations for a CANJEM cell with all jobs exposed at medium or high intensity were respectively 1.3 and 2.4 times higher relative to a cell with all jobs at low intensity. An overall trend of -3%/year in exposure was observed. Applying the model estimates to all 198 cells in CANJEM with some exposure assigned by the experts, the predicted 8-hour, personal wood dust GM concentrations by occupation for 1989 ranged from 0.48 to 1.96 mg m-3. CONCLUSIONS: The model provided estimates of wood dust concentrations for any CANJEM cell with exposure, applicable for quantitative risk assessment at the population level. This framework can be implemented for other agents represented in both CANJEM and CWED.
目的:CANJEM 一般人群职业暴露矩阵总结了在加拿大蒙特利尔进行的四项基于人群的癌症病例对照研究中,专家对 31673 种职业的评估。CANJEM 中的每个单元格的强度表示为专家分配的职业的有序(低、中、高)评级的相对分布。我们的目的是使用加拿大工作场所暴露数据库(CWED)中的加拿大历史测量值为 CANJEM 单元格应用定量浓度,以木尘暴露为例。
方法:我们从 CANJEM 中 1930 年至 2005 年间具有非零暴露概率的 31 种职业(2011 年加拿大国家职业分类)中选择了 5170 个人和区域木尘测量值,这些职业具有非零暴露概率。测量值是在 1981 年至 2003 年之间(中位数为 1989 年)采集的。采用职业为随机效应的贝叶斯分层模型对木尘浓度进行分析,并将采样持续时间、年份、样本类型(区域或个人)、省份以及 CANJEM 单元格中中高强度暴露的职业的相对比例作为固定效应。
结果:对于所有职业均处于中或高强度暴露的 CANJEM 单元格,估计的几何平均值(GM)浓度分别比所有职业均处于低强度暴露的单元格高 1.3 倍和 2.4 倍。观察到暴露呈 -3%/年的总体趋势。将模型估计值应用于 CANJEM 中所有 198 个具有专家分配的部分暴露的单元格,预测的 1989 年职业 8 小时个人木尘 GM 浓度范围为 0.48 至 1.96mgm-3。
结论:该模型提供了具有暴露的任何 CANJEM 单元格的木尘浓度估计值,适用于人群水平的定量风险评估。该框架可用于 CANJEM 和 CWED 中均有代表的其他剂。
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