中年男性的吸烟、中度α1-抗胰蛋白酶缺乏与肺功能
Smoking and intermediate alpha1-antitrypsin deficiency and lung function in middle-aged men.
作者信息
Larsson C, Eriksson S, Dirksen H
出版信息
Br Med J. 1977 Oct 8;2(6092):922-5. doi: 10.1136/bmj.2.6092.922.
Abstract
Lung function was evaluated in a representative population sample of 50-year-0ld men living in one Swedish city. Twenty-four smoking and 15 non-smoking men heterozygous for alpha1-antitrypsin deficiency--that is, with the protease-inhibitor (Pi1 phenotype MZ--were carefully matched for weight and smoking habit with Pi M controls. The pulmonary function of non-smoking Pi MZ subjects did not differ from that of non-smoking Pi M controls. In contrast, smoking heterozygotes showed a significant loss of elastic recoil, enlarged residual volumes, and increased closing capacity but no signs of obstructive ventilatory impairment. Most smoking Pi MZ individuals reported mild exertional dyspnoea.
摘要
在瑞典一个城市生活的50岁男性代表性人群样本中对肺功能进行了评估。24名吸烟且α1-抗胰蛋白酶缺乏杂合子的男性和15名非吸烟且α1-抗胰蛋白酶缺乏杂合子的男性——即具有蛋白酶抑制剂（Pi）表型MZ——在体重和吸烟习惯方面与Pi M对照进行了仔细匹配。非吸烟Pi MZ受试者的肺功能与非吸烟Pi M对照没有差异。相比之下，吸烟杂合子表现出明显的弹性回缩丧失、残气量增大和闭合容量增加，但没有阻塞性通气障碍的迹象。大多数吸烟Pi MZ个体报告有轻度运动性呼吸困难。
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Acta Physiol Scand. 1956 Feb 20;35(3-4):289-303. doi: 10.1111/j.1748-1716.1955.tb01286.x.
2
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3
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