Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
Department of Genetics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA; Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA 94305, USA.
Trends Cell Biol. 2019 Feb;29(2):97-116. doi: 10.1016/j.tcb.2018.09.004. Epub 2018 Oct 10.
The lifespan of an organism is strongly influenced by environmental factors (including diet) and by internal factors (notably reproductive status). Lipid metabolism is critical for adaptation to external conditions or reproduction. Interestingly, specific lipid profiles are associated with longevity, and increased uptake of certain lipids extends longevity in Caenorhabditis elegans and ameliorates disease phenotypes in humans. How lipids impact longevity, and how lipid metabolism is regulated during aging, is just beginning to be unraveled. This review describes recent advances in the regulation and role of lipids in longevity, focusing on the interaction between lipid metabolism and chromatin states in aging and age-related diseases.
生物体的寿命受到环境因素（包括饮食）和内部因素（特别是生殖状态）的强烈影响。脂质代谢对于适应外部条件或繁殖至关重要。有趣的是，特定的脂质谱与长寿相关，某些脂质的摄取增加可延长秀丽隐杆线虫的寿命并改善人类的疾病表型。脂质如何影响寿命，以及脂质代谢在衰老过程中如何被调节，才刚刚开始被揭示。本文综述了脂质在长寿中的调节作用和作用的最新进展，重点讨论了脂质代谢与衰老和与年龄相关疾病中染色质状态的相互作用。
