从 和 花中分离得到的新咖啡酰奎宁酸衍生物和黄烷酮糖苷及其生物活性。
New Caffeoylquinic Acid Derivatives and Flavanone Glycoside from the Flowers of and Their Bioactivities.
机构信息
College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
出版信息
Molecules. 2019 Feb 28;24(5):850. doi: 10.3390/molecules24050850.
The flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives (), a new flavanone glycoside (), and six reported flavanones (⁻) were isolated and identified from the flowers of . The chemical structures of all isolates were elucidated by the analysis of comprehensive spectroscopic data as well as by comparison with previously reported data. The isolated constituents ⁻ were evaluated for their neuroprotective activity, and compounds and displayed neuroprotective effects against hydrogen peroxide-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.
该花在中国和日本被广泛用作食品、饮料和治疗多种疾病的药物。在我们的工作中，从 花中分离并鉴定出两种新的咖啡酰奎宁酸衍生物 ()、一种新的黄烷酮糖苷 () 和六种已报道的黄烷酮 (⁻)。通过全面的光谱数据分析以及与以前报道的数据进行比较，确定了所有分离物的化学结构。对分离得到的成分 ⁻ 进行了神经保护活性评价，化合物 和 对人神经母细胞瘤 SH-SY5Y 细胞过氧化氢诱导的神经毒性具有神经保护作用。
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