Kiełczykowska Małgorzata, Polz-Dacewicz Małgorzata, Kopciał Ewelina, Mitrus Olga, Kurzepa Jacek, Marzec Zbigniew, Musik Irena
Chair and Department of Medical Chemistry, Medical University, Lublin, Poland.
Department of Virology, Medical University, Lublin, Poland.
Ann Agric Environ Med. 2020 Mar 17;27(1):129-133. doi: 10.26444/aaem/105926. Epub 2019 Apr 12.
Lithium has been used in medicine for almost seventy years. Besides beneficial effects, its therapy may cause serious side-effects, with kidney and liver being the organs most vulnerable to its harmful influence. Therefore, research on protective agents against lithium toxicity has been continuing for some time.
The aim of the present study is to evaluate the influence of additional selenium supplementation on lithium content, as well as homeostasis of the essential microelements iron, zinc, copper and manganese in kidney and liver of rats undergoing lithium exposure.
The study was performed on 4 groups of male Wistar rats (6 animals each) treated with: control - saline; Li-group - LiCO at a dose of 2.7 mg Li/kg b.w.; Se-group - NaSeO at a dose of 0.5 mg Se/kg b.w.; Li+Se-group - both LiCO and NaSeO at doses of 2.7 mg Li/kg b.w. and of 0.5 mg Se/kg b.w., respectively, in the form of water solutions by stomach tube, once a day for 3 weeks. The content of the studied elements in the organ samples was determined using flame atomic absorption spectroscopy (FAAS).
Lithium administered alone caused a significant increase in its content in liver and kidney. Additional supplementation with selenium reversed these effects, and did not markedly affect other studied microelements compared to control.
The obtained results suggest that selenium could be regarded as an adjuvant into lithium therapy. However, considering the limitations of the present study (the short duration, using only one dose and form of selenium) the continuation of the research seems to be necessary to clarify the influence of selenium supplementation on basic microelements and lithium accumulation in organs during lithium exposure.
锂在医学上已使用了近七十年。除了有益作用外，其治疗可能会引起严重的副作用，肾脏和肝脏是最易受其有害影响的器官。因此，针对锂毒性保护剂的研究已经持续了一段时间。
本研究的目的是评估额外补充硒对接受锂暴露的大鼠肾脏和肝脏中锂含量以及必需微量元素铁、锌、铜和锰的体内稳态的影响。
该研究对4组雄性Wistar大鼠（每组6只动物）进行处理：对照组——生理盐水；锂组——以2.7毫克锂/千克体重的剂量给予碳酸锂；硒组——以0.5毫克硒/千克体重的剂量给予亚硒酸钠；锂+硒组——分别以2.7毫克锂/千克体重和0.5毫克硒/千克体重的剂量给予碳酸锂和亚硒酸钠，通过胃管以水溶液形式给药，每天一次，持续3周。使用火焰原子吸收光谱法（FAAS）测定器官样本中所研究元素的含量。
单独给予锂会导致其在肝脏和肾脏中的含量显著增加。额外补充硒可逆转这些影响，并且与对照组相比，对其他所研究的微量元素没有明显影响。
所得结果表明，硒可被视为锂治疗的辅助剂。然而，考虑到本研究的局限性（持续时间短、仅使用一种剂量和形式的硒），似乎有必要继续进行研究，以阐明补充硒对锂暴露期间器官中基本微量元素和锂积累的影响。
