长链非编码RNA在中枢神经系统及神经退行性疾病中的作用
The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases.
作者信息
Wei Chang-Wei, Luo Ting, Zou Shan-Shan, Wu An-Shi
机构信息
Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
出版信息
Front Behav Neurosci. 2018 Sep 28;12:175. doi: 10.3389/fnbeh.2018.00175. eCollection 2018.
Abstract
Long noncoding RNAs (lncRNAs) refer to a group of noncoding RNAs (ncRNAs) that has a transcript of more than 200 nucleotides in length in eukaryotic cells. The lncRNAs regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels by multiple action modes. In this review, we describe the diverse roles reported for lncRNAs, and discuss how they could mechanistically be involved in the development of central nervous system (CNS) and neurodegenerative diseases. Further studies on the function of lncRNAs and their mechanism will help deepen our understanding of the development, function, and diseases of the CNS, and provide new ideas for the design and development of some therapeutic drugs.
摘要
长链非编码RNA（lncRNAs）是指真核细胞中一类转录本长度超过200个核苷酸的非编码RNA（ncRNAs）。lncRNAs通过多种作用模式在表观遗传、转录和转录后水平上调节基因表达。在本综述中，我们描述了lncRNAs所报道的多种作用，并讨论了它们在中枢神经系统（CNS）发育和神经退行性疾病中可能的作用机制。对lncRNAs功能及其机制的进一步研究将有助于加深我们对CNS的发育、功能和疾病的理解，并为一些治疗药物的设计和开发提供新思路。
相似文献
1
The Role of Long Noncoding RNAs in Central Nervous System and Neurodegenerative Diseases.长链非编码RNA在中枢神经系统及神经退行性疾病中的作用
Front Behav Neurosci. 2018 Sep 28;12:175. doi: 10.3389/fnbeh.2018.00175. eCollection 2018.
2
Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases.长非编码 RNA 在大脑发育、功能多样化和神经退行性疾病中的作用。
Brain Res Bull. 2013 Aug;97:69-80. doi: 10.1016/j.brainresbull.2013.06.001. Epub 2013 Jun 10.
3
New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases.微小 RNA 和长非编码 RNA 在最常见神经退行性疾病中的作用的新见解。
J Cell Biochem. 2019 Jun;120(6):8908-8918. doi: 10.1002/jcb.28361. Epub 2019 Jan 20.
4
Regulatory Roles of Long Non-Coding RNAs in the Central Nervous System and Associated Neurodegenerative Diseases.长链非编码RNA在中枢神经系统及相关神经退行性疾病中的调控作用
Front Cell Neurosci. 2017 Jun 30;11:175. doi: 10.3389/fncel.2017.00175. eCollection 2017.
5
Post-transcriptional Regulation of Genes Related to Biological Behaviors of Gastric Cancer by Long Noncoding RNAs and MicroRNAs.长链非编码RNA和微小RNA对胃癌生物学行为相关基因的转录后调控
J Cancer. 2017 Nov 12;8(19):4141-4154. doi: 10.7150/jca.22076. eCollection 2017.
6
Regulatory non-coding RNAs in nervous system development and disease.调控性非编码 RNA 在神经系统发育和疾病中的作用。
Front Biosci (Landmark Ed). 2019 Jun 1;24(7):1203-1240. doi: 10.2741/4776.
7
Long noncoding RNAs: Central to nervous system development.长链非编码RNA：神经系统发育的核心
Int J Dev Neurosci. 2016 Dec;55:109-116. doi: 10.1016/j.ijdevneu.2016.06.001. Epub 2016 Jun 11.
8
The Role of Long Noncoding RNAs in Neurodegenerative Diseases.长链非编码RNA在神经退行性疾病中的作用
Mol Neurobiol. 2017 Apr;54(3):2012-2021. doi: 10.1007/s12035-016-9793-6. Epub 2016 Feb 24.
9
Regulatory mechanisms of long noncoding RNAs in vertebrate central nervous system development and function.脊椎动物中枢神经系统发育和功能中长链非编码 RNA 的调控机制。
Neuroscience. 2013 Apr 3;235:200-14. doi: 10.1016/j.neuroscience.2013.01.022. Epub 2013 Jan 18.
10
The Long Non-Coding RNAs in Neurodegenerative Diseases: Novel Mechanisms of Pathogenesis.神经退行性疾病中的长链非编码RNA：发病机制的新机制
Curr Alzheimer Res. 2016;13(11):1219-1231. doi: 10.2174/1567205013666160622112234.
引用本文的文献
1
Isoform-level profiling of mA epitranscriptomic signatures in human brain.人类大脑中 mA 表观转录组特征的异构体水平分析。
Sci Adv. 2025 Aug 8;11(32):eadp0783. doi: 10.1126/sciadv.adp0783.
2
A cell-type-specific epigenetic mechanism encodes social investigatory behavior via Lrhcn1 and Hcn1.一种细胞类型特异性表观遗传机制通过Lrhcn1和Hcn1编码社会探究行为。
Sci Adv. 2025 Jun 6;11(23):eadt5400. doi: 10.1126/sciadv.adt5400. Epub 2025 Jun 4.
3
Downregulation of Lnc-ABCA12-3 modulates UBQLN1 expression and protein homeostasis pathways in amyotrophic lateral sclerosis.Lnc-ABCA12-3 的下调调节肌萎缩侧索硬化症中 UBQLN1 的表达和蛋白质平衡途径。
Sci Rep. 2024 Sep 13;14(1):21383. doi: 10.1038/s41598-024-72666-8.
4
Exploring the Frontier: Antisense Long Non-Coding RNAs as Key Regulators in Alzheimer's Disease.探索前沿：反义长链非编码RNA作为阿尔茨海默病的关键调节因子
Aging Dis. 2024 Aug 19;16(4):1793-1812. doi: 10.14336/AD.2024.0762.
5
The Association between Long Non-Coding RNAs and Alzheimer's Disease.长链非编码RNA与阿尔茨海默病之间的关联
Brain Sci. 2024 Aug 15;14(8):818. doi: 10.3390/brainsci14080818.
6
The expression analysis of long noncoding RNAs PCAT-1, PCAT-29, and MER11C in bipolar disorder.长链非编码 RNA PCAT-1、PCAT-29 和 MER11C 在双相情感障碍中的表达分析。
BMC Psychiatry. 2024 Jul 23;24(1):524. doi: 10.1186/s12888-024-05974-y.
7
Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, governs the glioma transcriptome, and impacts cell migration.长链非编码 RNA NEAT1 的异构体平衡受 RNA 结合蛋白 QKI 调控，调控胶质瘤转录组，并影响细胞迁移。
J Biol Chem. 2024 Aug;300(8):107595. doi: 10.1016/j.jbc.2024.107595. Epub 2024 Jul 18.
8
Hidden regulators: the emerging roles of lncRNAs in brain development and disease.隐藏的调控因子：长链非编码RNA在大脑发育和疾病中的新作用
Front Neurosci. 2024 May 22;18:1392688. doi: 10.3389/fnins.2024.1392688. eCollection 2024.
9
Noncoding RNAs in Alzheimer's Disease: Overview of Functional and Therapeutic Significance.非编码 RNA 在阿尔茨海默病中的作用：功能与治疗意义概述。
Curr Top Med Chem. 2024;24(19):1615-1634. doi: 10.2174/0115680266293212240405042540.
10
Unraveling Dysregulated Cell Signaling Pathways, Genetic and Epigenetic Mysteries of Parkinson's Disease.解析帕金森病失调的细胞信号通路、遗传和表观遗传之谜。
Mol Neurobiol. 2024 Nov;61(11):8928-8966. doi: 10.1007/s12035-024-04128-1. Epub 2024 Apr 4.
本文引用的文献
1
Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease.血浆长链非编码RNA BACE1作为阿尔茨海默病诊断的新型生物标志物。
BMC Neurol. 2018 Jan 9;18(1):4. doi: 10.1186/s12883-017-1008-x.
2
LncRNA NEAT1 promotes autophagy in MPTP-induced Parkinson's disease through stabilizing PINK1 protein.长链非编码RNA NEAT1通过稳定PINK1蛋白促进MPTP诱导的帕金森病中的自噬。
Biochem Biophys Res Commun. 2018 Feb 19;496(4):1019-1024. doi: 10.1016/j.bbrc.2017.12.149. Epub 2017 Dec 27.
3
Oxidative stress and cellular pathologies in Parkinson's disease.帕金森病中的氧化应激和细胞病理学。
Mol Brain. 2017 Nov 28;10(1):53. doi: 10.1186/s13041-017-0340-9.
4
Mechanisms of Long Non-Coding RNAs in the Assembly and Plasticity of Neural Circuitry.长非编码 RNA 在神经回路组装和可塑性中的作用机制。
Front Neural Circuits. 2017 Oct 23;11:76. doi: 10.3389/fncir.2017.00076. eCollection 2017.
5
Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation.人类长链非编码RNA对干细胞潜能和分化的调控
Stem Cells Int. 2017;2017:6374504. doi: 10.1155/2017/6374504. Epub 2017 Aug 30.
6
Regulatory Roles of Long Non-Coding RNAs in the Central Nervous System and Associated Neurodegenerative Diseases.长链非编码RNA在中枢神经系统及相关神经退行性疾病中的调控作用
Front Cell Neurosci. 2017 Jun 30;11:175. doi: 10.3389/fncel.2017.00175. eCollection 2017.
7
The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states.长链非编码 RNA NEAT1 对神经元活动有反应，并与过度兴奋状态有关。
Sci Rep. 2017 Jan 5;7:40127. doi: 10.1038/srep40127.
8
Distinct Hippocampal Expression Profiles of Long Non-coding RNAs in an Alzheimer's Disease Model.在阿尔茨海默病模型中长非编码 RNA 的海马体表达谱特征。
Mol Neurobiol. 2017 Sep;54(7):4833-4846. doi: 10.1007/s12035-016-0038-5. Epub 2016 Aug 8.
9
Long noncoding RNAs and Alzheimer's disease.长链非编码RNA与阿尔茨海默病
Clin Interv Aging. 2016 Jun 29;11:867-72. doi: 10.2147/CIA.S107037. eCollection 2016.
10
The Long Non-Coding RNAs in Neurodegenerative Diseases: Novel Mechanisms of Pathogenesis.神经退行性疾病中的长链非编码RNA：发病机制的新机制
Curr Alzheimer Res. 2016;13(11):1219-1231. doi: 10.2174/1567205013666160622112234.
Zotero 插件