Chung Soo Im, Lee Sang Chul, Yi Seong Joon, Kang Mi Young
Department of Food Science and Nutrition, Brain Korea 21 Plus, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea.
School of Applied Biosciences, Kyungpook National University, Daegu 41566, Korea.
Nutr Res Pract. 2018 Oct;12(5):365-370. doi: 10.4162/nrp.2018.12.5.365. Epub 2018 Sep 14.
BACKGROUND/OBJECTIVES: Oxidative stress is a major cause of cancer. This study investigated the effects of the ethanol extracts from germinated and non-germinated Keunnunjami rice, a blackish-purple pigmented cultivar with giant embryo, on selected human cancer cell lines and on the antioxidant defense system of mice fed with a high-fat diet.
MATERIALS/METHODS: High fat-fed mice were orally administered with either distilled water (HF) or extracts (0.25%, w/w) from brown (B), germinated brown (GB), Keunnunjami (K), and germinated Keunnunjami (GK) rice.
In comparison with the brown rice extract, Keunnunjami extract showed higher anticancer effect against cervical and gastric cell lines but lower anticancer activity on liver and colon cancer cells. Mice from the HF group showed significantly higher lipid peroxidation and lower antioxidant enzyme activities than the control group. However, the oxidative stress induced by high-fat diet markedly decreased in B, GB, K, and GK groups as compared with the HF group.
Germination may be an effective method for improving the anticancer and antioxidative properties of Keunnunjami rice and extracts from germinated Keunnunjami rice may serve as a therapeutic agent against cervical and gastric cancers and oxidative damage.
背景/目的：氧化应激是癌症的主要成因。本研究调查了发芽和未发芽的巨胚黑紫色品种金南芝麻米乙醇提取物对特定人类癌细胞系以及高脂饮食喂养小鼠抗氧化防御系统的影响。
材料/方法：给高脂喂养的小鼠口服蒸馏水（HF）或棕色（B）、发芽棕色（GB）、金南芝麻（K）和发芽金南芝麻（GK）米的提取物（0.25%，w/w）。
与糙米提取物相比，金南芝麻提取物对宫颈和胃细胞系显示出更高的抗癌效果，但对肝癌和结肠癌细胞的抗癌活性较低。HF组小鼠的脂质过氧化显著高于对照组，抗氧化酶活性则低于对照组。然而，与HF组相比，B、GB、K和GK组中高脂饮食诱导的氧化应激明显降低。
发芽可能是提高金南芝麻米抗癌和抗氧化特性的有效方法，发芽金南芝麻米提取物可作为对抗宫颈癌和胃癌以及氧化损伤的治疗剂。
