Tiainen Sanna, Kiviniemi Antti, Hautala Arto, Huikuri Heikki, Ukkola Olavi, Tokola Kari, Tulppo Mikko, Vasankari Tommi
Sports Institute of Finland, 19100 Vierumäki, Finland.
Department of Health and Exercise and Paavo Nurmi Center, University of Turku, 20540 Turku, Finland.
Antioxidants (Basel). 2018 Oct 16;7(10):144. doi: 10.3390/antiox7100144.
We investigated the effect of two-year home-based exercise training program on oxidized low-density lipoprotein LDL (ox-LDL) and high-density lipoprotein HDL (ox-HDL) lipids in patients with coronary artery disease (CAD), both with and without type-2 diabetes (T2D). Analysis of lipoprotein-oxidized lipids was based on the determination of baseline conjugated dienes in lipoprotein lipids. In order to study the effect of an exercise load on ox-LDL and ox-HDL lipids patients in both CAD and CAD + T2D intervention, groups were divided in three based on exercise load (high, medium, and low). During the two-year home-based exercise training program, the study showed that only higher training volume resulted in a decreased concentration of ox-LDL, while the two groups with lower training volumes showed no change. This result indicates that the training load needs to be sufficiently high in order to decrease the concentration of atherogenic ox-LDL lipids in patients with CAD and CAD + T2D. Interestingly, the concentration of ox-HDL did not change in any of the subgroups. This could indicate that the lipid peroxide-transporting capacity of HDL, suggested by results from exercise training studies in healthy adults, may not function similarly in CAD patients with or without T2D. Moreover, the lipid-lowering medication used may have had an influence on these results.
我们研究了为期两年的居家运动训练计划对冠心病（CAD）患者氧化型低密度脂蛋白（ox-LDL）和氧化型高密度脂蛋白（ox-HDL）血脂的影响，这些患者既有2型糖尿病（T2D）患者，也有非2型糖尿病患者。脂蛋白氧化血脂的分析基于脂蛋白脂质中基线共轭二烯的测定。为了研究运动负荷对CAD和CAD + T2D干预患者的ox-LDL和ox-HDL血脂的影响，根据运动负荷（高、中、低）将两组患者分为三组。在为期两年的居家运动训练计划中，研究表明，只有较高的训练量会导致ox-LDL浓度降低，而训练量较低的两组则没有变化。这一结果表明，训练负荷需要足够高，才能降低CAD和CAD + T2D患者中致动脉粥样硬化的ox-LDL血脂浓度。有趣的是，任何亚组中的ox-HDL浓度均未发生变化。这可能表明，健康成年人运动训练研究结果所提示的HDL脂质过氧化物转运能力，在有或没有T2D的CAD患者中可能不会以类似的方式发挥作用。此外，所使用的降脂药物可能对这些结果产生了影响。
